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    Sgcz sarcoglycan zeta [ Mus musculus (house mouse) ]

    Gene ID: 244431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgczprovided by MGI
    Official Full Name
    sarcoglycan zetaprovided by MGI
    Primary source
    MGI:MGI:2388820
    See related
    Ensembl:ENSMUSG00000039539 AllianceGenome:MGI:2388820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230085N17Rik
    Summary
    Predicted to be involved in cardiac muscle tissue development and heart contraction. Predicted to act upstream of or within membrane organization. Located in plasma membrane. Part of sarcoglycan complex. Orthologous to human SGCZ (sarcoglycan zeta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Sgcz in Genome Data Viewer
    Location:
    8 A4; 8 23.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (37984994..39128857, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (37517840..38661705, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21233 Neighboring gene predicted gene, 25126 Neighboring gene STARR-seq mESC enhancer starr_21236 Neighboring gene STARR-seq mESC enhancer starr_21237 Neighboring gene STARR-seq mESC enhancer starr_21238 Neighboring gene STARR-seq mESC enhancer starr_21239 Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene STARR-seq mESC enhancer starr_21240 Neighboring gene forkhead box N2 pseudogene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene nuclear encoded tRNA leucine 2 (anticodon CAG) Neighboring gene STARR-seq mESC enhancer starr_21243 Neighboring gene microRNA 383 Neighboring gene predicted gene, 18211 Neighboring gene STARR-seq mESC enhancer starr_21244 Neighboring gene STARR-seq mESC enhancer starr_21246 Neighboring gene STARR-seq mESC enhancer starr_21247 Neighboring gene predicted gene, 40493 Neighboring gene STARR-seq mESC enhancer starr_21248 Neighboring gene STARR-seq mESC enhancer starr_21249 Neighboring gene STARR-seq mESC enhancer starr_21250 Neighboring gene predicted gene, 23128 Neighboring gene STARR-seq mESC enhancer starr_21252 Neighboring gene STARR-seq mESC enhancer starr_21253 Neighboring gene STARR-positive B cell enhancer mm9_chr8:40240716-40241017 Neighboring gene tumor suppressor candidate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zeta-sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Shiga K, et al. Exp Cell Res, 2006 Jul 1. PMID 16635485
    2. Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture. Levy R, et al. BMC Genomics, 2015 Nov 26. PMID 26611327, Free PMC Article
    3. Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. Wheeler MT, et al. Hum Mol Genet, 2002 Sep 1. PMID 12189167
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zeta-sarcoglycan is an integral component of the sarcoglycan complex and is important in the pathogenesis of muscular dystrophy.
      Title: Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123465, MGC123466

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within membrane organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sarcoglycan complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zeta-sarcoglycan
    Names
    ZSG1
    zeta-SG

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145841.2 → NP_665840.2  zeta-sarcoglycan

      See identical proteins and their annotated locations for NP_665840.2

      Status: VALIDATED

      Source sequence(s)
      AK136779
      Consensus CDS
      CCDS22251.2
      UniProtKB/Swiss-Prot
      Q3UVZ2, Q8BX51, Q8K1E7
      UniProtKB/TrEMBL
      Q3SXX6
      Related
      ENSMUSP00000113912.2, ENSMUST00000118896.2
      Conserved Domains (1) summary
      pfam04790
      Location:38 → 296
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      37984994..39128857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509122.2 → XP_006509185.1  zeta-sarcoglycan isoform X3

      Conserved Domains (1) summary
      pfam04790
      Location:5 → 222
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    2. XM_006509120.5 → XP_006509183.1  zeta-sarcoglycan isoform X1

      See identical proteins and their annotated locations for XP_006509183.1

      UniProtKB/Swiss-Prot
      Q3UVZ2, Q8BX51, Q8K1E7
      UniProtKB/TrEMBL
      Q3SXX6
      Conserved Domains (1) summary
      pfam04790
      Location:38 → 296
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    3. XM_011242138.2 → XP_011240440.1  zeta-sarcoglycan isoform X2

      See identical proteins and their annotated locations for XP_011240440.1

      UniProtKB/TrEMBL
      Q3SXX6
      Conserved Domains (1) summary
      pfam04790
      Location:25 → 283
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    4. XM_011242139.4 → XP_011240441.1  zeta-sarcoglycan isoform X4

      Conserved Domains (1) summary
      pfam04790
      Location:38 → 143
      Sarcoglycan_1; Sarcoglycan complex subunit protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX51.1 GenPept UniProtKB/Swiss-Prot:Q8BX51

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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