Krt84 keratin 84 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt84provided by MGI
Official Full Name: keratin 84provided by MGI
Primary source: MGI:MGI:96700
See related: Ensembl:ENSMUSG00000044294 AllianceGenome:MGI:96700
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HRb-1; Krt2-3; Krt2-16
Summary: A structural constituent of skin epidermis. Involved in regulation of keratinocyte differentiation. Located in intermediate filament cytoskeleton. Is expressed in filiform papillae; skin; and tongue. Orthologous to human KRT84 (keratin 84). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 56.9 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101433461..101441255, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101525026..101532820, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
Title: E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of skin epidermis	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type II cuticular Hb4

Names: 65 kDa type II keratin; K84; keratin complex 2, basic, gene 16; keratin complex 2, gene 16; type II hair keratin Hb4; type-II keratin Kb24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008474.2 → NP_032500.2 keratin, type II cuticular Hb4

See identical proteins and their annotated locations for NP_032500.2

Status: VALIDATED

Source sequence(s)

AA738772, BC114971, BY779643, CF173770, CJ052880

Consensus CDS

CCDS27853.1

UniProtKB/Swiss-Prot

E9QMQ6, Q1RME6, Q61862, Q99M73

Related

ENSMUSP00000023720.8, ENSMUST00000023720.8

Conserved Domains (4) summary

pfam00038
Location:173 → 483

Filament; Intermediate filament protein

pfam16208
Location:16 → 169

Keratin_2_head; Keratin type II head

cl12013
Location:217 → 372

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl23720
Location:390 → 452

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)