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    ZFTA zinc finger translocation associated [ Homo sapiens (human) ]

    Gene ID: 65998, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZFTAprovided by HGNC
    Official Full Name
    zinc finger translocation associatedprovided by HGNC
    Primary source
    HGNC:HGNC:28449
    See related
    Ensembl:ENSG00000188070 MIM:615699; AllianceGenome:HGNC:28449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C11orf95
    Summary
    Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 10.0), endometrium (RPKM 8.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFTA in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63759892..63768775, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63749259..63758142, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63527364..63536247, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:63398741-63399940 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 1 Neighboring gene atlastin GTPase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438213-63438714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63438715-63439214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3441 Neighboring gene reticulon 3 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:63529087-63529846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3445 Neighboring gene RNA, 7SL, cytoplasmic 596, pseudogene Neighboring gene Sharpr-MPRA regulatory region 949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3446 Neighboring gene spindlin interactor and repressor of chromatin binding

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ependymoma-like tumor with mesenchymal differentiation (ELTMD) with ZFTA:NCOA1 fusion: A diagnostic challenge. Dorwal P, et al. Neuropathology, 2024 Jun. PMID 37931917
    2. C11orf95-RELA fusion present in a primary intracranial extra-axial ependymoma: Report of a case with literature review. Nambirajan A, et al. Neuropathology, 2016 Oct. PMID 27121356
    3. Biology and management of ependymomas. Wu J, et al. Neuro Oncol, 2016 Jul. PMID 27022130, Free PMC Article
    4. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Parker M, et al. Nature, 2014 Feb 27. PMID 24553141, Free PMC Article
    5. Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors. Nishio J. J Biomed Biotechnol, 2011. PMID 21274402, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.
      Title: CNS tumors with PLAGL1-fusion: beyond ZFTA and YAP1 in the genetic spectrum of supratentorial ependymomas.
    2. Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
      Title: Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma.
    3. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
      Title: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
    4. Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features.
      Title: Ependymoma with C11orf95-MAML2 fusion: presenting with granular cell and ganglion cell features.
    5. C11orf95-RELA fusion transcript is thought to be the driver genetic alteration leading to activation of the NFkB pathway in supratentorial ependymomas.
      Title: C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma.
    6. C11orf95-RELA fusions represent a unique novel mechanism leading to pathological activation of NF-kappaB signaling in supratentorial ependymomas.
      Title: Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway.
    7. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in eight further cases of chondroid lipomas.
      Title: Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3032

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger translocation-associated protein
    Names
    uncharacterized protein C11orf95

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144936.2 → NP_001138408.1  zinc finger translocation-associated protein

      See identical proteins and their annotated locations for NP_001138408.1

      Status: VALIDATED

      Source sequence(s)
      AP006289
      Consensus CDS
      CCDS44636.1
      UniProtKB/Swiss-Prot
      A6NLS7, C9JLR9, Q3C1V4
      Related
      ENSP00000482180.1, ENST00000433688.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      63759892..63768775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448662.2 → XP_024304430.1  zinc finger translocation-associated protein isoform X3

    2. XM_047427477.1 → XP_047283433.1  zinc finger translocation-associated protein isoform X1

    3. XM_047427478.1 → XP_047283434.1  zinc finger translocation-associated protein isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      63749259..63758142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369723.1 → XP_054225698.1  zinc finger translocation-associated protein isoform X3

    2. XM_054369721.1 → XP_054225696.1  zinc finger translocation-associated protein isoform X1

    3. XM_054369722.1 → XP_054225697.1  zinc finger translocation-associated protein isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023941.1: Suppressed sequence

      Description
      NM_023941.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C9JLR9.1 GenPept UniProtKB/Swiss-Prot:C9JLR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials