TRAP1 TNF receptor associated protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRAP1provided by HGNC
Official Full Name: TNF receptor associated protein 1provided by HGNC
Primary source: HGNC:HGNC:16264
See related: Ensembl:ENSG00000126602 MIM:606219; AllianceGenome:HGNC:16264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSP75; HSP 75; HSP90L; TRAP-1
Summary: This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (3658037..3717524, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (3685304..3744794, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (3708038..3767525, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
Title: TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
TRAP1 modulates mitochondrial biogenesis via PGC-1alpha/TFAM signalling pathway in colorectal cancer cells.
Title: TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells.
Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
Title: Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins.
Title: Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins.
Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.
Title: Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.
The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
Title: The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells.
Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer.
Title: Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer.
TRAP1 Chaperones the Metabolic Switch in Cancer.
Title: TRAP1 Chaperones the Metabolic Switch in Cancer.
TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation.
Title: TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation.
HIF1alpha-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
Title: HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of TNF receptor-associated protein 1 (TRAP1; HSP90L; HSP75) in Jurkat cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68351 (e-PCR)
- UniSTS:64794

csnpdnase1-pcr7-1 (e-PCR)
- UniSTS:257070

csnpdnase1-pcr8-1 (e-PCR)
- UniSTS:257071

RH103299 (e-PCR)
- UniSTS:97630

D16S2907 (e-PCR)
- UniSTS:153478

GDB:624544 (e-PCR)
- UniSTS:158346

D16S2942 (e-PCR)
- UniSTS:34973

RH45732 (e-PCR)
- UniSTS:91560

D16S2622 (e-PCR), detects polymorphism
- UniSTS:10448

SHGC-60637 (e-PCR)
- UniSTS:1777

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational attenuation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HTP more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: heat shock protein 75 kDa, mitochondrial

Names: TNFR-associated protein 1; heat shock protein family C member 5; testicular tissue protein Li 209; tumor necrosis factor type 1 receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033088.1 RefSeqGene

Range

5074..64561

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272049.2 → NP_001258978.1 heat shock protein 75 kDa, mitochondrial isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC006111, AK223205, AK299127, DB452880

Consensus CDS

CCDS61824.1

UniProtKB/TrEMBL

Q53FS6

Related

ENSP00000442070.1, ENST00000538171.5

Conserved Domains (3) summary

PRK05218
Location:34 → 649

PRK05218; heat shock protein 90; Provisional

pfam00183
Location:210 → 648

HSP90; Hsp90 protein

pfam02518
Location:60 → 205

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
NM_016292.3 → NP_057376.2 heat shock protein 75 kDa, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_057376.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF154108, BC018950, DB452880

Consensus CDS

CCDS10508.1

UniProtKB/Swiss-Prot

B4DR68, D3DUC8, F5H897, O43642, O75235, Q12931, Q9UHL5

UniProtKB/TrEMBL

A0A140VJY2, Q53FS6

Related

ENSP00000246957.5, ENST00000246957.10

Conserved Domains (1) summary

PRK05218
Location:87 → 702

PRK05218; heat shock protein 90; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

3658037..3717524 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011522345.3 → XP_011520647.1 heat shock protein 75 kDa, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_011520647.1

UniProtKB/TrEMBL

I3L0K7

Related

ENSP00000458166.1, ENST00000575671.5

Conserved Domains (3) summary

PRK05218
Location:2 → 562

PRK05218; heat shock protein 90; Provisional

pfam00183
Location:123 → 561

HSP90; Hsp90 protein

pfam02518
Location:2 → 118

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase