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    FAM99A family with sequence similarity 99 member A [ Homo sapiens (human) ]

    Gene ID: 387742, updated on 17-Sep-2024

    Summary

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    Official Symbol
    FAM99Aprovided by HGNC
    Official Full Name
    family with sequence similarity 99 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:32368
    See related
    Ensembl:ENSG00000205866 AllianceGenome:HGNC:32368
    Gene type
    ncRNA
    RefSeq status
    PREDICTED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in liver (RPKM 15.9) and placenta (RPKM 1.5) See more
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    Genomic context

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    See FAM99A in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1665599..1667856)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1749630..1751930)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1686829..1689086)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1653741-1654240 Neighboring gene keratin associated protein 5-5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1676043-1676647 Neighboring gene uncharacterized LOC124902609 Neighboring gene Sharpr-MPRA regulatory region 10567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1706195-1706964 Neighboring gene family with sequence similarity 99 member B Neighboring gene long intergenic non-protein coding RNA 2708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. In silico analysis of the association between long non-coding RNA family with sequence similarity 99 member A (FAM99A) and hepatic cancer. Sun M, et al. IET Syst Biol, 2023 Apr. PMID 36854891, Free PMC Article
    2. Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma. Mo M, et al. BMC Cancer, 2022 Oct 26. PMID 36289466, Free PMC Article
    3. Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance. Ge Q, et al. Blood Press Monit, 2022 Aug 1. PMID 35258024
    4. Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p. Xu B, et al. Braz J Med Biol Res, 2020. PMID 33111745, Free PMC Article
    5. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. He T, et al. Mol Med Rep, 2019 Aug. PMID 31173227

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The comprehensive roles of lncRNA FAM99A/FAM99B in hepatocellular carcinoma: Expressions, regulatory mechanisms and functional pathway analysis.
      Title: The comprehensive roles of lncRNA FAM99A/FAM99B in hepatocellular carcinoma: Expressions, regulatory mechanisms and functional pathway analysis.
    2. In silico analysis of the association between long non-coding RNA family with sequence similarity 99 member A (FAM99A) and hepatic cancer.
      Title: In silico analysis of the association between long non-coding RNA family with sequence similarity 99 member A (FAM99A) and hepatic cancer.
    3. Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma.
      Title: Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma.
    4. Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance.
      Title: Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance.
    5. Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p.
      Title: Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p.
    6. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis.
      Title: lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • family with sequence similarity 99 member A (non-protein coding)

    Clone Names

    • FLJ42833, DKFZp781M09150

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026643.1 RNA Sequence

      Status: PREDICTED

      Source sequence(s)
      AP006285
      Related
      ENST00000382167.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1665599..1667856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791792.1 Reference GRCh38.p14 PATCHES

      Range
      405575..407832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187584.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      147836..150093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187657.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      139693..141959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1749630..1751930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014374.1: Suppressed sequence

      Description
      NM_001014374.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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