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    P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 [ Mus musculus (house mouse) ]

    Gene ID: 57385, updated on 27-Nov-2024

    Summary

    Official Symbol
    P2ry4provided by MGI
    Official Full Name
    pyrimidinergic receptor P2Y, G-protein coupled, 4provided by MGI
    Primary source
    MGI:MGI:1926594
    See related
    Ensembl:ENSMUSG00000044359 AllianceGenome:MGI:1926594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2Y4; P2Y4R
    Summary
    Enables G protein-coupled UTP receptor activity. Acts upstream of or within cellular response to prostaglandin E stimulus and transepithelial chloride transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in glutamatergic synapse and presynaptic active zone membrane. Is expressed in skeletal muscle. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 7.1), large intestine adult (RPKM 3.5) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See P2ry4 in Genome Data Viewer
    Location:
    X C3; X 43.72 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99631964..99638533, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100588358..100594927, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene diacylglycerol O-acyltransferase 2-like 6 Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_47635 Neighboring gene arrestin 3, retinal Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled UTP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled UTP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyrimidine nucleotide binding IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    P2Y purinoceptor 4
    Names
    P2Y4 receptor
    purinergic receptor P2Y, G-protein coupled, 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020621.4NP_065646.1  P2Y purinoceptor 4

      See identical proteins and their annotated locations for NP_065646.1

      Status: VALIDATED

      Source sequence(s)
      AL671299
      Consensus CDS
      CCDS30303.1
      UniProtKB/Swiss-Prot
      Q9JJS7
      UniProtKB/TrEMBL
      Q0VBT7
      Related
      ENSMUSP00000055869.2, ENSMUST00000053373.2
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      99631964..99638533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528178.2XP_006528241.1  P2Y purinoceptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006528241.1

      UniProtKB/Swiss-Prot
      Q9JJS7
      UniProtKB/TrEMBL
      Q0VBT7
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_006528175.2XP_006528238.1  P2Y purinoceptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006528238.1

      UniProtKB/Swiss-Prot
      Q9JJS7
      UniProtKB/TrEMBL
      Q0VBT7
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_006528176.3XP_006528239.1  P2Y purinoceptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006528239.1

      UniProtKB/Swiss-Prot
      Q9JJS7
      UniProtKB/TrEMBL
      Q0VBT7
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. XM_006528177.2XP_006528240.1  P2Y purinoceptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006528240.1

      UniProtKB/Swiss-Prot
      Q9JJS7
      UniProtKB/TrEMBL
      Q0VBT7
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors