Polr2c polymerase (RNA) II (DNA directed) polypeptide C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Polr2cprovided by MGI
Official Full Name: polymerase (RNA) II (DNA directed) polypeptide Cprovided by MGI
Primary source: MGI:MGI:109299
See related: Ensembl:ENSMUSG00000031783 AllianceGenome:MGI:109299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RPB3; 33kDa; Rpo2-3; mRBP31
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and protein dimerization activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in 1st branchial arch; alimentary system; limb; and sensory organ. Orthologous to human POLR2C (RNA polymerase II subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 36.8), CNS E14 (RPKM 33.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.92 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95584078..95590870)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94857450..94864242)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_6240-6241:992007189:1 (e-PCR)
- UniSTS:231222

D83999 (e-PCR)
- UniSTS:160066

MARC_4899-4900:991938840:1 (e-PCR)
- UniSTS:231113

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA polymerase II, core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II, core complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II, core complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-directed RNA polymerase II subunit RPB3

Names: DNA-directed RNA polymerase II 33 kDa polypeptide; DNA-directed RNA polymerase II subunit C; RNA polymerase II 3; RNA polymerase II subunit 3; RNA polymerase II subunit B3; RPB31; RPB33

NP_033116.2

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009090.5 → NP_033116.2 DNA-directed RNA polymerase II subunit RPB3

See identical proteins and their annotated locations for NP_033116.2

Status: VALIDATED

Source sequence(s)

AC129606

Consensus CDS

CCDS40442.1

UniProtKB/Swiss-Prot

P97760, Q99M46

UniProtKB/TrEMBL

Q9DB22

Related

ENSMUSP00000105147.4, ENSMUST00000109521.4

Conserved Domains (1) summary

cd07031
Location:7 → 266

RNAP_II_RPB3; RPB3 subunit of Eukaryotic RNA polymerase II