Zfp418 zinc finger protein 418 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp418provided by MGI
Official Full Name: zinc finger protein 418provided by MGI
Primary source: MGI:MGI:2444763
See related: Ensembl:ENSMUSG00000034538 AllianceGenome:MGI:2444763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZNF418; A230102I05Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in microautophagy and regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within cardiac muscle hypertrophy; negative regulation of cell growth involved in cardiac muscle cell development; and negative regulation of protein phosphorylation. Is active in nucleus. Orthologous to human ZNF416 (zinc finger protein 416). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 1.0), CNS E14 (RPKM 1.0) and 25 other tissues See more
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Genomic context

Location:: 7 A1; 7 4.16 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (7174352..7186559)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (7171353..7183560)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microautophagy	ISO Inferred from Sequence Orthology more info
involved_in microautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 418

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146179.2 → NP_666291.2 zinc finger protein 418

See identical proteins and their annotated locations for NP_666291.2

Status: VALIDATED

Source sequence(s)

AC150745, AK039147, BB671687

Consensus CDS

CCDS39756.1

UniProtKB/Swiss-Prot

Q8BFS8

Related

ENSMUSP00000057159.8, ENSMUST00000051435.8

Conserved Domains (5) summary

smart00349
Location:25 → 66

KRAB; krueppel associated box

COG5048
Location:282 → 639

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:566 → 586

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:25 → 64

KRAB; KRAB box

pfam13465
Location:606 → 631

zf-H2C2_2; Zinc-finger double domain