Pld1 phospholipase D1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pld1provided by MGI
Official Full Name: phospholipase D1provided by MGI
Primary source: MGI:MGI:109585
See related: Ensembl:ENSMUSG00000027695 AllianceGenome:MGI:109585
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pld1a; Pld1b; mPLD1
Summary: Predicted to enable phospholipase D activity. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cisterna; cytoplasmic vesicle; and lamellipodium. Predicted to be active in cholinergic synapse; cytoplasmic vesicle; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 11.15 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (27992636..28187388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (27938459..28133362)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis.
Title: PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis.
Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
Title: Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells.
Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina.
Title: Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina.
RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
Title: RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.
Title: PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.
PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.
Title: PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury.
Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, beta-catenin-osteoprotegerin, PPAR-gamma and C/EBPalpha signaling axis.
Title: Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis.
Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
Title: Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.
Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.
Title: Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation.
Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity.
Title: Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fj80c09.x1 (e-PCR)
- UniSTS:199955

Pld1 (e-PCR), detects polymorphism
- UniSTS:507158

RH124503 (e-PCR)
- UniSTS:161325

RH127181 (e-PCR)
- UniSTS:207471

MHAa34f8.seq (e-PCR)
- UniSTS:125147

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables phospholipase D activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nutrient	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipase D1

Names: choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1

NP_001157528.1

EC 3.1.4.4

NP_001355596.1

EC 3.1.4.4

NP_001397459.1

EC 3.1.4.4

NP_001397460.1

EC 3.1.4.4

NP_001397461.1

EC 3.1.4.4

NP_032901.2

EC 3.1.4.4

XP_017174978.1

EC 3.1.4.4

XP_017174979.1

EC 3.1.4.4

XP_017174980.1

EC 3.1.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164056.2 → NP_001157528.1 phospholipase D1 isoform 1

See identical proteins and their annotated locations for NP_001157528.1

Status: VALIDATED

Source sequence(s)

AC114987, AC132149

Consensus CDS

CCDS17275.1

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

Q6NVF2

Related

ENSMUSP00000113810.2, ENSMUST00000120834.8

Conserved Domains (1) summary

PLN02866
Location:82 → 1021

PLN02866; phospholipase D
NM_001368667.2 → NP_001355596.1 phospholipase D1 isoform 2

Status: VALIDATED

Source sequence(s)

AC114987, AC132149

Consensus CDS

CCDS89617.1

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

D6RH77

Related

ENSMUSP00000118727.3, ENSMUST00000123539.8

Conserved Domains (1) summary

PLN02866
Location:82 → 1059

PLN02866; phospholipase D
NM_001410530.1 → NP_001397459.1 phospholipase D1 isoform 2

Status: VALIDATED

Source sequence(s)

AC114987, AC132149

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

D6RH77
NM_001410531.1 → NP_001397460.1 phospholipase D1 isoform 1

Status: VALIDATED

Source sequence(s)

AC114987, AC132149

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

Q6NVF2
NM_001410532.1 → NP_001397461.1 phospholipase D1 isoform 1

Status: VALIDATED

Source sequence(s)

AC114987, AC132149

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

Q6NVF2
NM_008875.5 → NP_032901.2 phospholipase D1 isoform 1

See identical proteins and their annotated locations for NP_032901.2

Status: VALIDATED

Source sequence(s)

AC114987, AC132149

Consensus CDS

CCDS17275.1

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

Q6NVF2

Related

ENSMUSP00000064694.5, ENSMUST00000067757.11

Conserved Domains (1) summary

PLN02866
Location:82 → 1021

PLN02866; phospholipase D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

27992636..28187388

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319490.3 → XP_017174979.1 phospholipase D1 isoform X1

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

D6RH77

Conserved Domains (1) summary

PLN02866
Location:82 → 1059

PLN02866; phospholipase D
XM_017319489.3 → XP_017174978.1 phospholipase D1 isoform X1

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

D6RH77

Conserved Domains (1) summary

PLN02866
Location:82 → 1059

PLN02866; phospholipase D
XM_017319491.3 → XP_017174980.1 phospholipase D1 isoform X1

UniProtKB/Swiss-Prot

O35911, Q9Z280

UniProtKB/TrEMBL

D6RH77

Conserved Domains (1) summary

PLN02866
Location:82 → 1059

PLN02866; phospholipase D