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    STMN4 stathmin 4 [ Homo sapiens (human) ]

    Gene ID: 81551, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STMN4provided by HGNC
    Official Full Name
    stathmin 4provided by HGNC
    Primary source
    HGNC:HGNC:16078
    See related
    Ensembl:ENSG00000015592 MIM:620740; AllianceGenome:HGNC:16078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RB3
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in microtubule depolymerization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in Golgi apparatus and growth cone. Predicted to be active in cytoplasm and neuron projection. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward brain (RPKM 50.0) See more
    Orthologs
    mouse all
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    Genomic context

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    See STMN4 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27235308..27258404, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (27512166..27535258, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27092825..27115921, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 548h-4 Neighboring gene MPRA-validated peak6966 silencer Neighboring gene uncharacterized LOC105379340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27093978-27094478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27094479-27094979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27099673-27100624 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:27132319-27132821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27132 Neighboring gene tripartite motif containing 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27183969-27184798 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27184956-27185152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19048 Neighboring gene Sharpr-MPRA regulatory region 9089 Neighboring gene protein tyrosine kinase 2 beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27141 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27219644-27220174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27153 Neighboring gene Sharpr-MPRA regulatory region 13363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27287852-27288568 Neighboring gene microRNA 6842

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of stathmin family genes in human tissues: non-neural-restricted expression for SCLIP. Bièche I, et al. Genomics, 2003 Apr. PMID 12676564
    2. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. Gavet O, et al. J Cell Sci, 1998 Nov. PMID 9788875
    3. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Greka A, et al. Nat Neurosci, 2003 Aug. PMID 12858178
    4. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
    5. Protein interactome reveals converging molecular pathways among autism disorders. Sakai Y, et al. Sci Transl Med, 2011 Jun 8. PMID 21653829, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111012

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stathmin-4
    Names
    stathmin-like 4
    stathmin-like protein B3
    stathmin-like-protein RB3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001283053.2 → NP_001269982.1  stathmin-4 isoform 2

      See identical proteins and their annotated locations for NP_001269982.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC090150, AI638208, AK297415
      Consensus CDS
      CCDS64854.1
      UniProtKB/Swiss-Prot
      Q9H169
      Related
      ENSP00000428428.1, ENST00000523048.5
      Conserved Domains (1) summary
      pfam00836
      Location:76 → 203
      Stathmin; Stathmin family

    2. NM_001283054.2 → NP_001269983.1  stathmin-4 isoform 3

      See identical proteins and their annotated locations for NP_001269983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
      Source sequence(s)
      AC090150, AI638208, BC111001
      Consensus CDS
      CCDS64852.1
      UniProtKB/Swiss-Prot
      B7Z2Z7, B7Z4I9, D3DSS8, D3DSS9, G5EA16, Q2TAB9, Q9H169
      Related
      ENSP00000265770.7, ENST00000265770.11
      Conserved Domains (1) summary
      pfam00836
      Location:49 → 184
      Stathmin; Stathmin family

    3. NM_001283055.2 → NP_001269984.1  stathmin-4 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001269984.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTR's and the coding region , compared to variant 1. This results in an isoform (4) that is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC090150, AI638208, AK295329
      Consensus CDS
      CCDS64851.1
      UniProtKB/Swiss-Prot
      Q9H169
      Related
      ENSP00000428474.1, ENST00000519997.5
      Conserved Domains (1) summary
      pfam00836
      Location:40 → 167
      Stathmin; Stathmin family

    4. NM_001394383.1 → NP_001381312.1  stathmin-4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:48 → 183
      Stathmin; Stathmin family

    5. NM_001394384.1 → NP_001381313.1  stathmin-4 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:40 → 175
      Stathmin; Stathmin family

    6. NM_001394385.1 → NP_001381314.1  stathmin-4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:49 → 176
      Stathmin; Stathmin family

    7. NM_001394386.1 → NP_001381315.1  stathmin-4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:17 → 152
      Stathmin; Stathmin family

    8. NM_001394387.1 → NP_001381316.1  stathmin-4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC090150

    9. NM_001394388.1 → NP_001381317.1  stathmin-4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC090150

    10. NM_030795.4 → NP_110422.2  stathmin-4 isoform 1

      See identical proteins and their annotated locations for NP_110422.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC090150, AI638208, BC011520
      Consensus CDS
      CCDS6055.1
      UniProtKB/Swiss-Prot
      Q9H169
      Related
      ENSP00000342538.4, ENST00000350889.9
      Conserved Domains (1) summary
      pfam00836
      Location:76 → 211
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      27235308..27258404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273652.5 → XP_005273709.1  stathmin-4 isoform X1

      UniProtKB/TrEMBL
      B7Z1W4, E7EVN3
      Related
      ENSP00000430389.1, ENST00000522908.1
      Conserved Domains (1) summary
      pfam00836
      Location:80 → 201
      Stathmin; Stathmin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      27512166..27535258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361305.1 → XP_054217280.1  stathmin-4 isoform X1

      UniProtKB/TrEMBL
      B7Z1W4, E7EVN3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H169.1 GenPept UniProtKB/Swiss-Prot:Q9H169

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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