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    Gars1 glycyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 353172, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gars1provided by MGI
    Official Full Name
    glycyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:2449057
    See related
    Ensembl:ENSMUSG00000029777 AllianceGenome:MGI:2449057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gars; Nmf249; Sgrp23; GENA202; Gena201
    Summary
    Enables glycine-tRNA ligase activity. Acts upstream of or within glycyl-tRNA aminoacylation. Located in extracellular exosome and secretory granule. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and urinary system. Used to study Charcot-Marie-Tooth disease type 2D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 46.2), CNS E18 (RPKM 40.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gars1 in Genome Data Viewer
    Location:
    6 B3; 6 27.29 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55014986..55056489)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55038001..55079504)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ES cell cis-regulatory motif 6a Neighboring gene gamma-glutamyl cyclotransferase Neighboring gene predicted gene, 38539 Neighboring gene STARR-seq mESC enhancer starr_15971 Neighboring gene STARR-seq mESC enhancer starr_15972 Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene STARR-seq mESC enhancer starr_15973 Neighboring gene predicted gene, 34358

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP:ATP adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glycine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glycine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in diadenosine tetraphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diadenosine tetraphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within glycyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial glycyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA aminoacylation for protein translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA aminoacylation for protein translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glycine--tRNA ligase
    Names
    AP-4-A synthetase
    ap4A synthetase
    diadenosine tetraphosphate synthetase
    glyRS
    storage granule protein 23
    NP_851009.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180678.3NP_851009.2  glycine--tRNA ligase

      See identical proteins and their annotated locations for NP_851009.2

      Status: VALIDATED

      Source sequence(s)
      AK012758, AV236862, BY309346
      Consensus CDS
      CCDS39492.1
      UniProtKB/Swiss-Prot
      Q3TMM4, Q3UK01, Q8VC67, Q9CZD3
      Related
      ENSMUSP00000003572.9, ENSMUST00000003572.10
      Conserved Domains (1) summary
      PLN02734
      Location:46714
      PLN02734; glycyl-tRNA synthetase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      55014986..55056489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)