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    Glp1r glucagon-like peptide 1 receptor [ Mus musculus (house mouse) ]

    Gene ID: 14652, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glp1rprovided by MGI
    Official Full Name
    glucagon-like peptide 1 receptorprovided by MGI
    Primary source
    MGI:MGI:99571
    See related
    Ensembl:ENSMUSG00000024027 AllianceGenome:MGI:99571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLP-1R; GLP1Rc
    Summary
    Predicted to enable glucagon receptor activity; glucagon-like peptide 1 receptor activity; and peptide hormone binding activity. Involved in several processes, including learning or memory; positive regulation of blood pressure; and response to psychosocial stress. Acts upstream of or within with a positive effect on hormone secretion. Acts upstream of or within post-translational protein targeting to membrane, translocation. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 40.4), duodenum adult (RPKM 18.2) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Glp1r in Genome Data Viewer
    Location:
    17 A3.3; 17 15.8 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31120841..31155484)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (30901867..30936510)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene predicted gene, 24661 Neighboring gene predicted gene, 41561 Neighboring gene STARR-seq mESC enhancer starr_42315 Neighboring gene predicted gene, 41562 Neighboring gene uromodulin-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucagon receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucagon receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glucagon-like peptide 1 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucagon-like peptide 1 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucagon-like peptide 1 receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucagon stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-translational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to psychosocial stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    glucagon-like peptide 1 receptor
    Names
    GLP-1 receptor
    GLP-1-R

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021332.2NP_067307.2  glucagon-like peptide 1 receptor precursor

      See identical proteins and their annotated locations for NP_067307.2

      Status: VALIDATED

      Source sequence(s)
      DQ093397
      Consensus CDS
      CCDS37542.1
      UniProtKB/Swiss-Prot
      O35659, Q1JQR8
      UniProtKB/TrEMBL
      Q104P0, Q3ZAW0
      Related
      ENSMUSP00000110221.2, ENSMUST00000114574.3
      Conserved Domains (2) summary
      pfam00002
      Location:141398
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:59128
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31120841..31155484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)