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    Dusp29 dual specificity phosphatase 29 [ Mus musculus (house mouse) ]

    Gene ID: 435391, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dusp29provided by MGI
    Official Full Name
    dual specificity phosphatase 29provided by MGI
    Primary source
    MGI:MGI:3647127
    See related
    Ensembl:ENSMUSG00000063821 AllianceGenome:MGI:3647127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dupd1; EG435391
    Summary
    Enables MAP kinase phosphatase activity. Involved in glucose homeostasis; muscle cell differentiation; and negative regulation of ERK1 and ERK2 cascade. Located in cytoplasm and nucleus. Orthologous to human DUSP29 (dual specificity phosphatase 29). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.7), mammary gland adult (RPKM 0.7) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Dusp29 in Genome Data Viewer
    Location:
    14 A3; 14 11.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21726605..21764644, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21676565..21714576, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30363 Neighboring gene STARR-seq mESC enhancer starr_36134 Neighboring gene STARR-positive B cell enhancer ABC_E8945 Neighboring gene STARR-positive B cell enhancer ABC_E605 Neighboring gene STARR-positive B cell enhancer ABC_E4100 Neighboring gene K(lysine) acetyltransferase 6B Neighboring gene STARR-seq mESC enhancer starr_36143 Neighboring gene STARR-seq mESC enhancer starr_36148 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 13B Neighboring gene predicted gene 15935 Neighboring gene dual specificity phosphatase 13a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity phosphatase 29
    Names
    dual specificity phosphatase DUPD1
    dual specificity phosphatase and pro isomerase domain containing 1
    NP_001013848.1
    NP_001405798.1
    XP_036014638.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013826.3NP_001013848.1  dual specificity phosphatase 29

      Status: VALIDATED

      Source sequence(s)
      AC148978, AC151533
      Consensus CDS
      CCDS26863.1
      UniProtKB/Swiss-Prot
      B2RW26, Q8BK84
      Related
      ENSMUSP00000073534.6, ENSMUST00000073870.7
      Conserved Domains (1) summary
      cd14575
      Location:44203
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1
    2. NM_001418869.1NP_001405798.1  dual specificity phosphatase 29

      Status: VALIDATED

      Source sequence(s)
      AC148978, AC151533
      UniProtKB/Swiss-Prot
      B2RW26, Q8BK84

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21726605..21764644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158745.1XP_036014638.1  dual specificity phosphatase 29 isoform X1

      Conserved Domains (1) summary
      cd14575
      Location:55214
      DUPD1; dual specificity phosphatase and pro isomerase domain containing 1