Bzw2 basic leucine zipper and W2 domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bzw2provided by MGI
Official Full Name: basic leucine zipper and W2 domains 2provided by MGI
Primary source: MGI:MGI:1914162
See related: Ensembl:ENSMUSG00000020547 AllianceGenome:MGI:1914162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5mp1; Bdm2; HSPC028; 1110001I24Rik
Summary: Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; cardiovascular system; and genitourinary system. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 47.3), CNS E14 (RPKM 41.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 16.42 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (36141834..36206922, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (36091835..36156841, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
Title: BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: eIF5-mimic protein 1

Names: basic leucine zipper and W2 domain-containing protein 2; brain development-related molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025840.3 → NP_080116.2 eIF5-mimic protein 1

See identical proteins and their annotated locations for NP_080116.2

Status: VALIDATED

Source sequence(s)

AK160544, BQ032572, BY009345

Consensus CDS

CCDS25884.1

UniProtKB/Swiss-Prot

Q2L4X1, Q91VK1, Q9D0N4

UniProtKB/TrEMBL

Q3V199

Related

ENSMUSP00000020856.5, ENSMUST00000020856.6

Conserved Domains (1) summary

cd11560
Location:218 → 408

W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

36141834..36206922 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515166.4 → XP_006515229.1 eIF5-mimic protein 1 isoform X1

UniProtKB/TrEMBL

Q3V199

Related

ENSMUST00000221521.2

Conserved Domains (1) summary

cl17013
Location:218 → 369

W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon