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    Mrpl22 mitochondrial ribosomal protein L22 [ Mus musculus (house mouse) ]

    Gene ID: 216767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrpl22provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L22provided by MGI
    Primary source
    MGI:MGI:1333794
    See related
    Ensembl:ENSMUSG00000020514 AllianceGenome:MGI:1333794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L22mt; Rpml25; HSPC158; MRP-L22; MRP-L25; E030011D16Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; early conceptus; genitourinary system; and gut. Orthologous to human MRPL22 (mitochondrial ribosomal protein L22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 15.0), liver E14.5 (RPKM 13.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl22 in Genome Data Viewer
    Location:
    11 B1.3; 11 35.89 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58060850..58070406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58170043..58179580)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10677 Neighboring gene CCR4-NOT transcription complex, subunit 8 Neighboring gene predicted gene 12247 Neighboring gene STARR-seq mESC enhancer starr_29600 Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E5229 Neighboring gene predicted gene 12250 Neighboring gene STARR-positive B cell enhancer ABC_E8877 Neighboring gene interferon gamma induced GTPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article
    2. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
    3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    4. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    5. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL22m
    Names
    39S ribosomal protein L22, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403973.1 → NP_001390902.1  large ribosomal subunit protein uL22m precursor

      Status: VALIDATED

      Source sequence(s)
      AL672182, AL928857
      UniProtKB/Swiss-Prot
      Q8BK04, Q8BU88

    2. NM_175001.5 → NP_778166.2  large ribosomal subunit protein uL22m precursor

      See identical proteins and their annotated locations for NP_778166.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AL928857
      Consensus CDS
      CCDS24724.1
      UniProtKB/Swiss-Prot
      Q8BK04, Q8BU88
      Related
      ENSMUSP00000020820.2, ENSMUST00000020820.2
      Conserved Domains (1) summary
      pfam00237
      Location:71 → 172
      Ribosomal_L22; Ribosomal protein L22p/L17e

    RNA

    1. NR_166467.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928857

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58060850..58070406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532854.4 → XP_006532917.1  large ribosomal subunit protein uL22m isoform X2

      See identical proteins and their annotated locations for XP_006532917.1

      Conserved Domains (1) summary
      pfam00237
      Location:1 → 92
      Ribosomal_L22; Ribosomal protein L22p/L17e
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU88.1 GenPept UniProtKB/Swiss-Prot:Q8BU88

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