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    Brsk2 BR serine/threonine kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 75770, updated on 4-Jan-2025

    Summary

    Official Symbol
    Brsk2provided by MGI
    Official Full Name
    BR serine/threonine kinase 2provided by MGI
    Primary source
    MGI:MGI:1923020
    See related
    Ensembl:ENSMUSG00000053046 AllianceGenome:MGI:1923020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SADA; SAD-A; 4833424K13Rik
    Summary
    Enables protein kinase binding activity and tau-protein kinase activity. Involved in several processes, including microtubule cytoskeleton organization involved in establishment of planar polarity; regulation of axonogenesis; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within neuron projection morphogenesis and peptidyl-serine phosphorylation. Predicted to be located in distal axon and endoplasmic reticulum. Predicted to be active in centrosome. Is expressed in several structures, including central nervous system and retina. Orthologous to human BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in whole brain E14.5 (RPKM 31.8), CNS E14 (RPKM 28.8) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Brsk2 in Genome Data Viewer
    Location:
    7 F5; 7 87.43 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141503488..141557981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141949751..142004244)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene toll interacting protein Neighboring gene STARR-seq mESC enhancer starr_20497 Neighboring gene predicted gene, 32539 Neighboring gene microRNA 3104 Neighboring gene STARR-seq mESC enhancer starr_20498 Neighboring gene MOB kinase activator 2 Neighboring gene predicted gene, 25416

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 36
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables ATPase binding  
    enables ATPase binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding PubMed 
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    enables tau-protein kinase activity  
    enables tau-protein kinase activity PubMed 
    enables tau-protein kinase activity  
    enables tau-protein kinase activity PubMed 
    Items 1 - 25 of 36
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in ERAD pathway  
    involved_in ERAD pathway  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in G2/M transition of mitotic cell cycle  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in axonogenesis  
    involved_in axonogenesis PubMed 
    involved_in cell division  
    involved_in chromatin remodeling  
    involved_in establishment of cell polarity  
    acts_upstream_of_or_within establishment of cell polarity PubMed 
    involved_in establishment of cell polarity PubMed 
    involved_in establishment of cell polarity PubMed 
    involved_in exocytosis  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
    involved_in microtubule cytoskeleton organization involved in establishment of planar polarity PubMed 
    involved_in mitotic cell cycle checkpoint signaling  
    acts_upstream_of_or_within neuron differentiation PubMed 
    involved_in neuron differentiation PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of axonogenesis PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
    involved_in regulation of neuron projection development PubMed 
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    is_active_in centrosome  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in distal axon  
    located_in distal axon  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase BRSK2
    Names
    BR serine/threonine-protein kinase 2
    brain-specific serine/threonine-protein kinase 2
    serine/threonine-protein kinase SAD-A
    NP_001009929.1
    NP_001009930.1
    NP_001263692.1
    NP_083702.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009929.3NP_001009929.1  serine/threonine-protein kinase BRSK2 isoform beta

      See identical proteins and their annotated locations for NP_001009929.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a 3' coding exon and contains an additional 3' UTR exon and uses an alternate splice junction at the 5' end of the last exon compared to isoform 3. The resulting isoform (beta) has a shorter and distinct C-terminus compared to isoform gamma.
      Source sequence(s)
      AK158574, AL603836, AL772165
      Consensus CDS
      CCDS22023.1
      UniProtKB/TrEMBL
      G3UXM5
      Related
      ENSMUSP00000077330.6, ENSMUST00000078200.12
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    2. NM_001009930.3NP_001009930.1  serine/threonine-protein kinase BRSK2 isoform gamma

      See identical proteins and their annotated locations for NP_001009930.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (gamma).
      Source sequence(s)
      AK158574, AL603836, AL772165, BE986320
      Consensus CDS
      CCDS22022.1
      UniProtKB/TrEMBL
      G3UXM5
      Related
      ENSMUSP00000074969.6, ENSMUST00000075528.12
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    3. NM_001276763.1NP_001263692.1  serine/threonine-protein kinase BRSK2 isoform delta

      See identical proteins and their annotated locations for NP_001263692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region and 3' UTR, compared to variant 3. The resulting protein (isoform delta) is shorter than isoform gamma.
      Source sequence(s)
      AL603836, AL772165
      UniProtKB/TrEMBL
      G3FEZ6, G3UXM5
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    4. NM_029426.2NP_083702.1  serine/threonine-protein kinase BRSK2 isoform alpha

      See identical proteins and their annotated locations for NP_083702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame 3' exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 3. The resulting isoform (alpha) has a shorter and distinct C-terminus compared to isoform gamma.
      Source sequence(s)
      AL603836, AL772165
      Consensus CDS
      CCDS22021.1
      UniProtKB/TrEMBL
      G3UXM5
      Related
      ENSMUSP00000018971.9, ENSMUST00000018971.15
      Conserved Domains (2) summary
      cd14340
      Location:298351
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:18271
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141503488..141557981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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