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    CSN3 casein kappa [ Homo sapiens (human) ]

    Gene ID: 1448, updated on 10-Dec-2024

    Summary

    Official Symbol
    CSN3provided by HGNC
    Official Full Name
    casein kappaprovided by HGNC
    Primary source
    HGNC:HGNC:2446
    See related
    Ensembl:ENSG00000171209 MIM:601695; AllianceGenome:HGNC:2446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KCA; CSNK; CNS10; CSN10
    Summary
    Involved in lactation and protein stabilization. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward salivary gland (RPKM 13.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CSN3 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70238381..70251432)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73578064..73590918)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71104098..71117149)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene odontogenic, ameloblast associated Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71086538-71086690 Neighboring gene follicular dendritic cell secreted protein Neighboring gene calcium binding protein, spermatid associated 1 Neighboring gene submaxillary gland androgen regulated protein 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lactation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394997.1NP_001381926.1  kappa-casein precursor

      Status: VALIDATED

      Source sequence(s)
      AC105347
      Consensus CDS
      CCDS3538.1
      UniProtKB/Swiss-Prot
      P07498, Q13575
      Related
      ENSP00000304822.3, ENST00000304954.4
      Conserved Domains (1) summary
      pfam00997
      Location:21171
      Casein_kappa; Kappa casein
    2. NM_005212.3NP_005203.2  kappa-casein precursor

      See identical proteins and their annotated locations for NP_005203.2

      Status: VALIDATED

      Source sequence(s)
      AC105347, BG191674, X66417
      Consensus CDS
      CCDS3538.1
      UniProtKB/Swiss-Prot
      P07498, Q13575
      Conserved Domains (1) summary
      pfam00997
      Location:21171
      Casein_kappa; Kappa casein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70238381..70251432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007761.2XP_016863250.1  kappa-casein isoform X1

      UniProtKB/Swiss-Prot
      P07498, Q13575
      Related
      ENSP00000508633.1, ENST00000689459.1
      Conserved Domains (1) summary
      pfam00997
      Location:21171
      Casein_kappa; Kappa casein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73578064..73590918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348974.1XP_054204949.1  kappa-casein isoform X1