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    NOCT nocturnin [ Homo sapiens (human) ]

    Gene ID: 25819, updated on 10-Dec-2024

    Summary

    Official Symbol
    NOCTprovided by HGNC
    Official Full Name
    nocturninprovided by HGNC
    Primary source
    HGNC:HGNC:14254
    See related
    Ensembl:ENSG00000151014 MIM:608468; AllianceGenome:HGNC:14254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOC; CCR4L; Ccr4c; CCRN4L
    Summary
    The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 15.3), liver (RPKM 6.4) and 18 other tissues See more
    Orthologs
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    Genomic context

    See NOCT in Genome Data Viewer
    Location:
    4q31.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (139015781..139045939)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (142335696..142365540)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (139936935..139967093)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NIN1 (RPN12) binding protein 1 homolog pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:139568198-139569043 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:139578592-139579140 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:139579689-139580237 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:139580238-139580785 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:139580786-139581334 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:139581335-139581882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:139660090-139660734 Neighboring gene GATA motif-containing MPRA enhancer 163 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:139696241-139696424 Neighboring gene uncharacterized LOC105377448 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:139764110-139765309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:139787241-139787742 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:139821109-139821298 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:139831913-139832494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21914 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:139854116-139854670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:139898379-139899200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21916 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:139935295-139936494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:139949204-139949704 Neighboring gene uncharacterized LOC124900780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:139951907-139952731 Neighboring gene RNA, U6 small nuclear 531, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15694 Neighboring gene Sharpr-MPRA regulatory region 15356 Neighboring gene E74 like ETS transcription factor 2 Neighboring gene RNA, 7SL, cytoplasmic 382, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC78549, MGC142054, MGC142060, MGC4120817

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity  
    enables NADP phosphatase activity PubMed 
    enables NADPH phosphatase activity PubMed 
    enables mRNA binding  
    enables metal ion binding  
    enables poly(A)-specific ribonuclease activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in NADP metabolic process PubMed 
    involved_in P-body assembly  
    involved_in circadian regulation of gene expression  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA  
    involved_in mRNA stabilization  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of osteoblast differentiation  
    involved_in positive regulation of fat cell differentiation  
    involved_in regulation of circadian rhythm  
    involved_in regulation of embryonic development  
    involved_in response to lipopolysaccharide  
    involved_in transcription by RNA polymerase II PubMed 
    Component Evidence Code Pubs
    located_in P-body  
    located_in cytoplasm  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in nucleoplasm  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    nocturnin
    Names
    CCR4 carbon catabolite repression 4-like
    CCR4 protein homolog
    CCR4-like (carbon catabolite repression 4, S.cerevisiae)
    carbon catabolite repression 4-like protein
    circadian deadenylase NOC
    NP_036250.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012118.4NP_036250.2  nocturnin

      See identical proteins and their annotated locations for NP_036250.2

      Status: REVIEWED

      Source sequence(s)
      AC093602, BC113494, HY067201
      Consensus CDS
      CCDS3743.1
      UniProtKB/Swiss-Prot
      D3DNY5, Q14D51, Q9HD93, Q9HD94, Q9HD95, Q9UK39
      Related
      ENSP00000280614.2, ENST00000280614.4
      Conserved Domains (1) summary
      cd09096
      Location:144423
      Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      139015781..139045939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      142335696..142365540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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