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    RNASE10 ribonuclease A family member 10 (inactive) [ Homo sapiens (human) ]

    Gene ID: 338879, updated on 19-Dec-2024

    Summary

    Official Symbol
    RNASE10provided by HGNC
    Official Full Name
    ribonuclease A family member 10 (inactive)provided by HGNC
    Primary source
    HGNC:HGNC:19275
    See related
    Ensembl:ENSG00000182545 MIM:621046; AllianceGenome:HGNC:19275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAH1; RNASE9
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including defense response to Gram-positive bacterium; positive regulation of flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See RNASE10 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20504233..20513884)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14701150..14711005)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20972392..20982043)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:20928913-20929879 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:20929880-20930845 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:20937332-20937836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8079 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:20945841-20946029 Neighboring gene purine nucleoside phosphorylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8080 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:20995293-20995503 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 1 Neighboring gene SET pseudogene 1

    Genomic regions, transcripts, and products

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables RNA nuclease activity IKR
    Inferred from Key Residues
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inactive ribonuclease-like protein 10
    Names
    ribonuclease A H1
    ribonuclease, RNase A family, 10 (non-active)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012975.3NP_001012993.1  inactive ribonuclease-like protein 10 precursor

      See identical proteins and their annotated locations for NP_001012993.1

      Status: VALIDATED

      Source sequence(s)
      AL355075
      Consensus CDS
      CCDS32035.1
      UniProtKB/Swiss-Prot
      A2RUQ3, B4DKY4, Q5GAN6
      UniProtKB/TrEMBL
      W0UTC4
      Related
      ENSP00000333358.5, ENST00000328444.6
      Conserved Domains (1) summary
      cd00163
      Location:108213
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
    2. NM_001386206.3NP_001373135.2  inactive ribonuclease-like protein 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AL355075
      Consensus CDS
      CCDS32035.1
      UniProtKB/Swiss-Prot
      A2RUQ3, B4DKY4, Q5GAN6
      UniProtKB/TrEMBL
      W0UTC4
      Related
      ENSP00000392996.2, ENST00000430083.2
      Conserved Domains (1) summary
      cd00163
      Location:108213
      RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      20504233..20513884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791796.1 Reference GRCh38.p14 PATCHES

      Range
      706914..716565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      14701150..14711005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)