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    ZNF316 zinc finger protein 316 [ Homo sapiens (human) ]

    Gene ID: 100131017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZNF316provided by HGNC
    Official Full Name
    zinc finger protein 316provided by HGNC
    Primary source
    HGNC:HGNC:13843
    See related
    Ensembl:ENSG00000205903 AllianceGenome:HGNC:13843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MZF-3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 6.9), fat (RPKM 4.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF316 in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6637318..6658279)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6756509..6777459)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6676949..6697910)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6628794-6629632 Neighboring gene integrator complex subunit 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:6637314-6637506 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6653371-6654124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6654125-6654878 Neighboring gene zinc finger protein 853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6663565-6664065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25632 Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6698799-6699300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6703791-6704291 Neighboring gene uncharacterized LOC124901583 Neighboring gene zinc finger protein 33B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A quantitative atlas of mitotic phosphorylation. Dephoure N, et al. Proc Natl Acad Sci U S A, 2008 Aug 5. PMID 18669648, Free PMC Article
    2. Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells. Yang Z, et al. Vaccines (Basel), 2022 Nov 29. PMID 36560452, Free PMC Article
    3. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    4. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Gupta R, et al. Cell, 2018 May 3. PMID 29656893, Free PMC Article
    5. A High-Density Map for Navigating the Human Polycomb Complexome. Hauri S, et al. Cell Rep, 2016 Oct 4. PMID 27705803

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686B2320

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 316

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278559.2 → NP_001265488.1  zinc finger protein 316

      See identical proteins and their annotated locations for NP_001265488.1

      Status: VALIDATED

      Source sequence(s)
      AC073343
      Consensus CDS
      CCDS75563.1
      UniProtKB/Swiss-Prot
      A6NFI3
      Related
      ENSP00000477706.1, ENST00000382252.6
      Conserved Domains (4) summary
      smart00349
      Location:158 → 218
      KRAB; krueppel associated box
      COG5048
      Location:746 → 933
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:833 → 853
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:705 → 730
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      6637318..6658279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446618.2 → XP_024302386.1  zinc finger protein 316 isoform X1

      UniProtKB/Swiss-Prot
      A6NFI3
      Conserved Domains (4) summary
      smart00349
      Location:158 → 218
      KRAB; krueppel associated box
      COG5048
      Location:746 → 933
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:833 → 853
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:705 → 730
      zf-H2C2_2; Zinc-finger double domain

    2. XM_024446619.2 → XP_024302387.1  zinc finger protein 316 isoform X1

      UniProtKB/Swiss-Prot
      A6NFI3
      Conserved Domains (4) summary
      smart00349
      Location:158 → 218
      KRAB; krueppel associated box
      COG5048
      Location:746 → 933
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:833 → 853
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:705 → 730
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      6756509..6777459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356942.1 → XP_054212917.1  zinc finger protein 316 isoform X1

    2. XM_054356943.1 → XP_054212918.1  zinc finger protein 316 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NFI3.1 GenPept UniProtKB/Swiss-Prot:A6NFI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials