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    ZDHHC4 zinc finger DHHC-type palmitoyltransferase 4 [ Homo sapiens (human) ]

    Gene ID: 55146, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZDHHC4provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 4provided by HGNC
    Primary source
    HGNC:HGNC:18471
    See related
    Ensembl:ENSG00000136247 AllianceGenome:HGNC:18471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF374
    Summary
    Enables palmitoyltransferase activity. Involved in positive regulation of innate immune response and protein localization to plasma membrane. Located in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 21.7), testis (RPKM 20.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC4 in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6577454..6589374)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6696620..6708547)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6617085..6629005)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17950 Neighboring gene uncharacterized LOC101927325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25629 Neighboring gene Grid2 interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6576361-6577340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17953 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6617713-6618328 Neighboring gene uncharacterized LOC124901582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6628794-6629632 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:6637314-6637506 Neighboring gene integrator complex subunit 15 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6653371-6654124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6654125-6654878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6663565-6664065 Neighboring gene zinc finger protein 853

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis. Zhao C, et al. Oncogenesis, 2022 May 23. PMID 35606353, Free PMC Article
    2. Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability. Ebersole B, et al. PLoS One, 2015. PMID 26535572, Free PMC Article
    3. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, et al. Cell Rep, 2019 Jan 2. PMID 30605677
    4. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. Gorleku OA, et al. J Biol Chem, 2011 Nov 11. PMID 21926431, Free PMC Article
    5. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. Grimsby S, et al. FEBS Lett, 2004 Nov 5. PMID 15527767

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10479

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC4
    Names
    DHHC-4
    probable palmitoyltransferase ZDHHC4
    zinc finger DHHC domain-containing protein 4
    zinc finger DHHC-type containing 4
    zinc finger protein 374
    zinc finger, DHHC domain containing 4
    NP_001127859.1
    NP_001127860.1
    NP_001127861.1
    NP_001358221.1
    NP_001358222.1
    NP_001358223.1
    NP_001358224.1
    NP_001358225.1
    NP_001358226.1
    NP_001358227.1
    NP_001358228.1
    NP_060576.1
    XP_005249853.1
    XP_047276520.1
    XP_047276521.1
    XP_047276522.1
    XP_047276523.1
    XP_054214544.1
    XP_054214545.1
    XP_054214546.1
    XP_054214547.1
    XP_054214548.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134387.2 → NP_001127859.1  palmitoyltransferase ZDHHC4 isoform b

      See identical proteins and their annotated locations for NP_001127859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742, AK001341, AK223532, BQ185277, BQ925460, CN365375
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Related
      ENSP00000379941.2, ENST00000396713.6
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    2. NM_001134388.2 → NP_001127860.1  palmitoyltransferase ZDHHC4 isoform b

      See identical proteins and their annotated locations for NP_001127860.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742, AK001341, AK223532, BQ185277, BQ925460
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Related
      ENSP00000379935.2, ENST00000396707.6
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    3. NM_001134389.2 → NP_001127861.1  palmitoyltransferase ZDHHC4 isoform b

      See identical proteins and their annotated locations for NP_001127861.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742, AK001341, BQ185277
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Related
      ENSP00000337475.6, ENST00000335965.11
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    4. NM_001371292.1 → NP_001358221.1  palmitoyltransferase ZDHHC4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (a).
      Source sequence(s)
      AC079742
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 307
      DHHC; DHHC palmitoyltransferase

    5. NM_001371293.1 → NP_001358222.1  palmitoyltransferase ZDHHC4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    6. NM_001371294.1 → NP_001358223.1  palmitoyltransferase ZDHHC4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    7. NM_001371295.1 → NP_001358224.1  palmitoyltransferase ZDHHC4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    8. NM_001371296.1 → NP_001358225.1  palmitoyltransferase ZDHHC4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    9. NM_001371297.1 → NP_001358226.1  palmitoyltransferase ZDHHC4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Related
      ENSP00000379937.1, ENST00000396709.5
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    10. NM_001371298.1 → NP_001358227.1  palmitoyltransferase ZDHHC4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC079742
      Conserved Domains (1) summary
      pfam01529
      Location:131 → 272
      DHHC; DHHC palmitoyltransferase

    11. NM_001371299.1 → NP_001358228.1  palmitoyltransferase ZDHHC4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC079742
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 232
      DHHC; DHHC palmitoyltransferase

    12. NM_018106.4 → NP_060576.1  palmitoyltransferase ZDHHC4 isoform b

      See identical proteins and their annotated locations for NP_060576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1-4 and 6-10 all encode the same isoform (b).
      Source sequence(s)
      AC079742, AK001341, AK223532, BQ185277
      Consensus CDS
      CCDS5352.1
      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Related
      ENSP00000385027.3, ENST00000405731.7
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_163912.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079742

    2. NR_163913.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079742

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      6577454..6589374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420565.1 → XP_047276521.1  palmitoyltransferase ZDHHC4 isoform X1

      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8

    2. XM_047420564.1 → XP_047276520.1  palmitoyltransferase ZDHHC4 isoform X1

      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8

    3. XM_047420566.1 → XP_047276522.1  palmitoyltransferase ZDHHC4 isoform X2

    4. XM_005249796.4 → XP_005249853.1  palmitoyltransferase ZDHHC4 isoform X1

      See identical proteins and their annotated locations for XP_005249853.1

      UniProtKB/Swiss-Prot
      A4D2N9, Q53EV7, Q6FIB5, Q9H0R9, Q9NPG8
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 292
      DHHC; DHHC palmitoyltransferase

    5. XM_047420567.1 → XP_047276523.1  palmitoyltransferase ZDHHC4 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      6696620..6708547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358570.1 → XP_054214545.1  palmitoyltransferase ZDHHC4 isoform X1

    2. XM_054358569.1 → XP_054214544.1  palmitoyltransferase ZDHHC4 isoform X1

    3. XM_054358572.1 → XP_054214547.1  palmitoyltransferase ZDHHC4 isoform X2

    4. XM_054358571.1 → XP_054214546.1  palmitoyltransferase ZDHHC4 isoform X1

    5. XM_054358573.1 → XP_054214548.1  palmitoyltransferase ZDHHC4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NPG8.1 GenPept UniProtKB/Swiss-Prot:Q9NPG8

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