KLF3 KLF transcription factor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLF3provided by HGNC
Official Full Name: KLF transcription factor 3provided by HGNC
Primary source: HGNC:HGNC:16516
See related: Ensembl:ENSG00000109787 MIM:609392; AllianceGenome:HGNC:16516
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BKLF
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon (RPKM 22.1), gall bladder (RPKM 19.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (38664199..38701517)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (38633299..38670624)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (38665820..38703138)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-92b-3p augments colon cancer development through inhibiting KLF3.
Title: microRNA-92b-3p augments colon cancer development through inhibiting KLF3.
Molecular Expression and Prognostic Implications of Kruppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma.
Title: Molecular Expression and Prognostic Implications of Krüppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma.
Decreased KLF3 Expression via miR-660-5p Targeting Suppresses Gastric Cancer Cell Progression.
Title: Decreased KLF3 Expression via miR-660-5p Targeting Suppresses Gastric Cancer Cell Progression.
Pan-cancer analysis of Kruppel-like factor 3 and its carcinogenesis in pancreatic cancer.
Title: Pan-cancer analysis of Krüppel-like factor 3 and its carcinogenesis in pancreatic cancer.
KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin Signaling Pathway.
Title: KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway.
microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3.
Title: microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3.
Hepatic Meteorin-like and Kruppel-like Factor 3 are Associated with Weight Loss and Liver Injury.
Title: Hepatic Meteorin-like and Krüppel-like Factor 3 are Associated with Weight Loss and Liver Injury.
Bone mesenchymal stem cells (BMSCs)-derived exosomal microRNA-21-5p regulates Kruppel-like factor 3 (KLF3) to promote osteoblast proliferation in vitro.
Title: Bone mesenchymal stem cells (BMSCs)-derived exosomal microRNA-21-5p regulates Kruppel-like factor 3 (KLF3) to promote osteoblast proliferation in vitro.
Exosome miR-23a-3p from Osteoblast Alleviates Spinal Cord Ischemia/Reperfusion Injury by Down-Regulating KLF3-Activated CCNL2 Transcription.
Title: Exosome miR-23a-3p from Osteoblast Alleviates Spinal Cord Ischemia/Reperfusion Injury by Down-Regulating KLF3-Activated CCNL2 Transcription.
Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Kruppel-like factor 3 (KLF3) promotes osteosarcoma progression.
Title: Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of genetic loci associated with Helicobacter pylori serologic status. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-67940 (e-PCR)
- UniSTS:59694

SGC31793 (e-PCR)
- UniSTS:32590

D4S2599E (e-PCR)
- UniSTS:150990

RH36206 (e-PCR)
- UniSTS:39886

SHGC-59602 (e-PCR)
- UniSTS:46550

KLF3_1583 (e-PCR)
- UniSTS:462299

SHGC-67230 (e-PCR)
- UniSTS:42726

SHGC-67372 (e-PCR)
- UniSTS:47603

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to peptide	IEA Inferred from Electronic Annotation more info
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: Krueppel-like factor 3

Names: CACCC-box-binding protein BKLF; Kruppel like factor 3; Kruppel-like factor 3 (basic); TEF-2; basic Kruppel-like factor; basic krueppel-like factor; basic kruppel like factor; transcript ch138

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016531.6 → NP_057615.3 Krueppel-like factor 3

See identical proteins and their annotated locations for NP_057615.3

Status: VALIDATED

Source sequence(s)

AC021860, AF285837, BU689914, DB246277

Consensus CDS

CCDS3444.1

UniProtKB/Swiss-Prot

P57682, Q6PIR1, Q86TN0, Q9P2X6

UniProtKB/TrEMBL

B2R8P9

Related

ENSP00000261438.5, ENST00000261438.10

Conserved Domains (4) summary

sd00017
Location:262 → 284

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:260 → 284

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:306 → 331

zf-H2C2_2; Zinc-finger double domain

cd21577
Location:49 → 260

KLF3_N; N-terminal domain of Kruppel-like factor 3