U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Mzf1 myeloid zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 109889, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mzf1provided by MGI
    Official Full Name
    myeloid zinc finger 1provided by MGI
    Primary source
    MGI:MGI:107457
    See related
    Ensembl:ENSMUSG00000030380 AllianceGenome:MGI:107457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mzf2; Mzf-2; Zfp98; Znf42; Zfp121
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in bladder; central nervous system; male associated reproductive structure; testis; and urethra of male. Orthologous to human MZF1 (myeloid zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 1.8), frontal lobe adult (RPKM 1.7) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mzf1 in Genome Data Viewer
    Location:
    7 A1; 7 7.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12777074..12792244, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13042303..13054764, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:13619992-13620293 Neighboring gene charged multivesicular body protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E6513 Neighboring gene ubiquitin-conjugating enzyme E2M Neighboring gene STARR-positive B cell enhancer ABC_E2223 Neighboring gene STARR-seq mESC enhancer starr_18069 Neighboring gene vomeronasal 1 receptor 85 Neighboring gene predicted gene 4270

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm  

    General protein information

    Preferred Names
    myeloid zinc finger 1
    Names
    Myeloid zinc finger protein 1
    Myeloid zinc finger protein 2
    myeloid-specific retinoic acid-responsive zinc finger protein
    zinc finger protein 121
    zinc finger protein 98

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290452.2NP_001277381.1  myeloid zinc finger 1 isoform 2

      See identical proteins and their annotated locations for NP_001277381.1

      Status: VALIDATED

      Source sequence(s)
      AC121301
      UniProtKB/TrEMBL
      A1L357
      Conserved Domains (5) summary
      COG5048
      Location:144524
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:250270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:165186
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:475500
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001290453.2NP_001277382.1  myeloid zinc finger 1 isoform 3

      See identical proteins and their annotated locations for NP_001277382.1

      Status: VALIDATED

      Source sequence(s)
      AC121301
      Conserved Domains (3) summary
      COG5048
      Location:74454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281301
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:180200
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001382820.2NP_001369749.1  myeloid zinc finger 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121301
      Conserved Domains (1) summary
      smart00431
      Location:42153
      SCAN; leucine rich region
    4. NM_001420326.1NP_001407255.1  myeloid zinc finger 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121301
      UniProtKB/TrEMBL
      A1L358
    5. NM_001420327.1NP_001407256.1  myeloid zinc finger 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121301
    6. NM_001420329.1NP_001407258.1  myeloid zinc finger 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121301
    7. NM_001420330.1NP_001407259.1  myeloid zinc finger 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121301
    8. NM_001420331.1NP_001407260.1  myeloid zinc finger 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121301
    9. NM_001420332.1NP_001407261.1  myeloid zinc finger 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121301
    10. NM_145819.3NP_665818.2  myeloid zinc finger 1 isoform 1

      See identical proteins and their annotated locations for NP_665818.2

      Status: VALIDATED

      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS20826.1
      UniProtKB/TrEMBL
      A1L358
      Related
      ENSMUSP00000138387.2, ENSMUST00000182515.8
      Conserved Domains (7) summary
      smart00431
      Location:42153
      SCAN; leucine rich region
      COG5048
      Location:337728
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:544564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358379
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42129
      SCAN; SCAN domain
      pfam13465
      Location:668693
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12777074..12792244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539469.4XP_006539532.3  myeloid zinc finger 1 isoform X3

      Conserved Domains (1) summary
      smart00431
      Location:121232
      SCAN; leucine rich region
    2. XM_006539465.5XP_006539528.1  myeloid zinc finger 1 isoform X1

      See identical proteins and their annotated locations for XP_006539528.1

      UniProtKB/TrEMBL
      S4R1L6
      Related
      ENSMUSP00000138271.2, ENSMUST00000182490.2
      Conserved Domains (4) summary
      smart00431
      Location:121232
      SCAN; leucine rich region
      COG5048
      Location:416807
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:623643
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:522542
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_006539466.5XP_006539529.1  myeloid zinc finger 1 isoform X2

      Conserved Domains (4) summary
      smart00431
      Location:64175
      SCAN; leucine rich region
      COG5048
      Location:359750
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:566586
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:465485
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_017321928.3XP_017177417.1  myeloid zinc finger 1 isoform X6

      Conserved Domains (1) summary
      smart00431
      Location:121232
      SCAN; leucine rich region

    External link. Please review our privacy policy.