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    Cept1 choline/ethanolaminephosphotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 99712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cept1provided by MGI
    Official Full Name
    choline/ethanolaminephosphotransferase 1provided by MGI
    Primary source
    MGI:MGI:2139793
    See related
    Ensembl:ENSMUSG00000040774 AllianceGenome:MGI:2139793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mCEPT1; 9930118K05Rik
    Summary
    Enables phosphotransferase activity, for other substituted phosphate groups. Acts upstream of or within phosphatidylcholine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in alimentary system; cranium; nervous system; nose; and urinary system. Orthologous to human CEPT1 (choline/ethanolamine phosphotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.4), liver E18 (RPKM 5.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cept1 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.49 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106409576..106455118, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106502260..106547802, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chitinase-like 6 Neighboring gene STARR-seq mESC enhancer starr_08648 Neighboring gene STARR-positive B cell enhancer ABC_E6101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106252568-106252751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106264918-106265101 Neighboring gene RIKEN cDNA 2010016I18 gene Neighboring gene STARR-seq mESC enhancer starr_08649 Neighboring gene DENN domain containing 2D Neighboring gene STARR-seq mESC enhancer starr_08650 Neighboring gene STARR-positive B cell enhancer ABC_E6102 Neighboring gene DNA-damage regulated autophagy modulator 2 Neighboring gene STARR-seq mESC enhancer starr_08651 Neighboring gene STARR-seq mESC enhancer starr_08652 Neighboring gene STARR-seq mESC enhancer starr_08653 Neighboring gene ligand dependent nuclear receptor interacting factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10205 Neighboring gene CD53 antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Funai K, et al. Diabetes, 2016 Feb. PMID 26512026, Free PMC Article
    2. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. Butler PL, et al. J Biol Chem, 2010 Feb 26. PMID 20018880, Free PMC Article
    3. Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. Kulinski A, et al. J Biol Chem, 2002 Aug 30. PMID 12072432
    4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-alkenyl-2-acylglycerol choline phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol cholinephosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolaminephosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    choline/ethanolaminephosphotransferase 1
    Names
    1-alkenyl-2-acylglycerol choline phosphotransferase
    NP_001280623.1
    NP_001344747.1
    NP_001344748.1
    NP_598630.2
    XP_006502534.1
    XP_011238638.1
    XP_036019375.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293694.1 → NP_001280623.1  choline/ethanolaminephosphotransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001280623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and contains an alternate exon but maintains the reading frame compared to variant 1. The encoded isoform (4) is the same length as isoform 1, but contains a distinct internal segment.
      Source sequence(s)
      AC117200, AC140380
      Consensus CDS
      CCDS79995.1
      UniProtKB/Swiss-Prot
      Q8BGS7
      Related
      ENSMUSP00000037277.8, ENSMUST00000039153.14
      Conserved Domains (1) summary
      cl00453
      Location:43 → 407
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. NM_001357818.1 → NP_001344747.1  choline/ethanolaminephosphotransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117200, AC140380, CO425529, CX223901
      Consensus CDS
      CCDS17723.1
      UniProtKB/Swiss-Prot
      Q8BGS7, Q8VC64
      Conserved Domains (1) summary
      cl00453
      Location:43 → 407
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    3. NM_001357819.1 → NP_001344748.1  choline/ethanolaminephosphotransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117200, AC140380
      Consensus CDS
      CCDS17723.1
      UniProtKB/Swiss-Prot
      Q8BGS7, Q8VC64
      Conserved Domains (1) summary
      cl00453
      Location:43 → 407
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    4. NM_133869.4 → NP_598630.2  choline/ethanolaminephosphotransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_598630.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AK037116, BY226430
      Consensus CDS
      CCDS17723.1
      UniProtKB/Swiss-Prot
      Q8BGS7, Q8VC64
      Related
      ENSMUSP00000065743.5, ENSMUST00000068301.11
      Conserved Domains (1) summary
      cl00453
      Location:43 → 407
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      106409576..106455118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502471.5 → XP_006502534.1  choline/ethanolaminephosphotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006502534.1

      UniProtKB/Swiss-Prot
      Q8BGS7, Q8VC64
      Related
      ENSMUSP00000112509.2, ENSMUST00000121231.8
      Conserved Domains (1) summary
      cl00453
      Location:43 → 407
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    2. XM_011240336.3 → XP_011238638.1  choline/ethanolaminephosphotransferase 1 isoform X2

      Conserved Domains (1) summary
      cl00453
      Location:43 → 209
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    3. XM_036163482.1 → XP_036019375.1  choline/ethanolaminephosphotransferase 1 isoform X2

      Conserved Domains (1) summary
      cl00453
      Location:43 → 209
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RNA

    1. XR_375610.4 RNA Sequence

    2. XR_001783787.3 RNA Sequence

    3. XR_003954431.2 RNA Sequence

    4. XR_001783786.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGS7.1 GenPept UniProtKB/Swiss-Prot:Q8BGS7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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