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    Inka2 inka box actin regulator 2 [ Mus musculus (house mouse) ]

    Gene ID: 109050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inka2provided by MGI
    Official Full Name
    inka box actin regulator 2provided by MGI
    Primary source
    MGI:MGI:1923497
    See related
    Ensembl:ENSMUSG00000048458 AllianceGenome:MGI:1923497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam212b; 6530418L21Rik
    Summary
    Predicted to enable protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; dorsal root ganglion; heart; and olfactory epithelium. Orthologous to human INKA2 (inka box actin regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 15.1), frontal lobe adult (RPKM 12.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Inka2 in Genome Data Viewer
    Location:
    3 F2.2; 3 46.44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105611915..105628158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105704599..105720842)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related family, member 3, opposite strand Neighboring gene potassium voltage-gated channel, Shal-related family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6095 Neighboring gene STARR-positive B cell enhancer ABC_E8804 Neighboring gene STARR-positive B cell enhancer ABC_E2091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:105507469-105507578 Neighboring gene DEAD box helicase 20 Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208 Neighboring gene predicted gene 5547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inka2 expression in smooth muscle cells and its involvement in cell migration. Yamada S, et al. Biochem Biophys Res Commun, 2023 Feb 5. PMID 36586159
    2. Control of cell migration by the novel protein phosphatase-2A interacting protein inka2. Akiyama H, et al. Cell Tissue Res, 2020 Jun. PMID 31975032
    3. Expression profiles of inka2 in the murine nervous system. Iwasaki Y, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26292052
    4. Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development. Yamada S, et al. PLoS Genet, 2022 Oct. PMID 36301793, Free PMC Article
    5. Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature. Ohayon D, et al. iScience, 2021 Jul 23. PMID 34296073, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inka2 expression in smooth muscle cells and its involvement in cell migration.
      Title: Inka2 expression in smooth muscle cells and its involvement in cell migration.
    2. Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
      Title: Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
    3. Control of cell migration by the novel protein phosphatase-2A interacting protein inka2.
      Title: Control of cell migration by the novel protein phosphatase-2A interacting protein inka2.
    4. In the present study, we identified a novel gene, designated as inka2, which is related to inka1
      Title: Expression profiles of inka2 in the murine nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    PAK4-inhibitor INKA2
    Names
    MInca-r
    family with sequence similarity 212, member B
    induced in neural crest by AP2-alpha protein-related homolog
    protein FAM212B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163356.1 → NP_001156828.1  PAK4-inhibitor INKA2 isoform 2

      See identical proteins and their annotated locations for NP_001156828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) utilizes an alternate first exon, compared to variant 2, resulting in (predicted) use of an internal translation start site and a shorter protein isoform (2).
      Source sequence(s)
      AC139316, AK078368
      Consensus CDS
      CCDS51035.1
      UniProtKB/Swiss-Prot
      Q80VY2
      Related
      ENSMUSP00000095874.3, ENSMUST00000098273.3
      Conserved Domains (1) summary
      pfam15342
      Location:120 → 159
      FAM212; FAM212 family

    2. NM_175398.4 → NP_780607.2  PAK4-inhibitor INKA2 isoform 1

      See identical proteins and their annotated locations for NP_780607.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC139316, AK078368, BY290400
      Consensus CDS
      CCDS17710.1
      UniProtKB/Swiss-Prot
      Q80VY2, Q8C5H0, Q8CCA1
      Related
      ENSMUSP00000069212.8, ENSMUST00000066610.8
      Conserved Domains (1) summary
      pfam15342
      Location:139 → 178
      FAM212; FAM212 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      105611915..105628158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VY2.1 GenPept UniProtKB/Swiss-Prot:Q80VY2

    Gene LinkOut

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