Fer FER tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ferprovided by MGI
Official Full Name: FER tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:105917
See related: Ensembl:ENSMUSG00000000127 AllianceGenome:MGI:105917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fer; Fert; Fert2; C330004K01Rik
Summary: Enables protein kinase activity and protein phosphatase 1 binding activity. Involved in several processes, including cell surface receptor signaling pathway; cell-cell adhesion mediated by cadherin; and negative regulation of mast cell activation involved in immune response. Acts upstream of with a positive effect on positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including cell adhesion; chemotaxis; and protein autophosphorylation. Predicted to be located in several cellular components, including adherens junction; chromatin; and cytoplasmic side of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Predicted to colocalize with cell junction; cytoskeleton; and lamellipodium. Is expressed in central nervous system and retina. Orthologous to human FER (FER tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 3.4), whole brain E14.5 (RPKM 3.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.1; 17 33.06 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (64136945..64453515)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (63862073..64146519)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells.
Title: SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells.
Sperm from mice targeted with a kinase-inactivating mutation in Fer failed to undergo capacitation-associated increases in tyrosine phosphorylation.
Title: The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm.
levels of FER were elevated in ovarian cancer cell lines relative to those in immortalized normal surface epithelial cells and that suppression of FER attenuated the motility and invasive properties of these cancer cells
Title: HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer.
directed mitochondrial accumulation of FerT endowed nonmalignant cells with tumor-forming ability
Title: Oncogenic properties of a spermatogenic meiotic variant of fer kinase expressed in somatic cells.
a critical role of Fer in PDGF-BB-induced STAT3 activation and cell transformation.
Title: The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo.
Fer is a novel inhibitory kinase for neutrophil chemotaxis toward end target chemoattractants through modulation of PI3K activity.
Title: Fer kinase limits neutrophil chemotaxis toward end target chemoattractants.
FER kinase plays a critical role in oocyte meiotic spindle microtubule dynamics and may have an additional function in GVBD.
Title: Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes.
NRP1 has a role in signaling Sema3A-evoked neuronal death through Fer in cortical neurons
Title: Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons.
FerT coexist in the acroplaxome with phosphorylated cortactin, a regulator of F-actin dynamics
Title: Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids.
association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer
Title: Continuous association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV082135 (e-PCR)
- UniSTS:181052

PMC86629P1 (e-PCR)
- UniSTS:273538

AI010628 (e-PCR)
- UniSTS:250013

RH118372 (e-PCR)
- UniSTS:160993

Fert2 (e-PCR), detects polymorphism
- UniSTS:143085

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc-epsilon receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Fc-epsilon receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Kit signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Sertoli cell development	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction assembly	IEA Inferred from Electronic Annotation more info
involved_in adherens junction disassembly	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to macrophage colony-stimulating factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in diapedesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mast cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to platelet-derived growth factor	IDA Inferred from Direct Assay more info	PubMed
involved_in seminiferous tubule development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
colocalizes_with cell junction	ISO Inferred from Sequence Orthology more info
colocalizes_with cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with lamellipodium	ISO Inferred from Sequence Orthology more info
colocalizes_with lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase Fer

Names: fer (fms/fps related) protein kinase, testis specific 2; p94-Fer; proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase Fer

NP_001033086.2

EC 2.7.10.2

NP_001273344.1

EC 2.7.10.2

NP_001390288.1

EC 2.7.10.2

NP_001390289.1

EC 2.7.10.2

NP_001390290.1

EC 2.7.10.2

NP_032026.2

EC 2.7.10.2

XP_006523703.1

EC 2.7.10.2

XP_006523704.1

EC 2.7.10.2

XP_006523706.1

EC 2.7.10.2

XP_006523708.1

EC 2.7.10.2

XP_006523713.1

EC 2.7.10.2

XP_017172733.1

EC 2.7.10.2

XP_036016207.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037997.4 → NP_001033086.2 tyrosine-protein kinase Fer isoform a

See identical proteins and their annotated locations for NP_001033086.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC110517, AC140339, CT010469

Consensus CDS

CCDS28936.1

UniProtKB/Swiss-Prot

P70451, Q61561, Q6PEE5, Q80UI3, Q8C481, Q9EQ77

Related

ENSMUSP00000000129.7, ENSMUST00000000129.14

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:454 → 539

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:567 → 817

PKc_like; Protein Kinases, catalytic domain
NM_001286415.1 → NP_001273344.1 tyrosine-protein kinase Fer isoform c

See identical proteins and their annotated locations for NP_001273344.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR exon, and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) lacks an internal segment, compared to isoform a.

Source sequence(s)

BC058100

Consensus CDS

CCDS89132.1

UniProtKB/Swiss-Prot

P70451

Related

ENSMUSP00000156523.2, ENSMUST00000233190.2

Conserved Domains (4) summary

cd10361
Location:396 → 481

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:506 → 757

Pkinase_Tyr; Protein tyrosine kinase

cl12013
Location:5 → 180

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21453
Location:509 → 759

PKc_like; Protein Kinases, catalytic domain
NM_001403359.1 → NP_001390288.1 tyrosine-protein kinase Fer isoform d

Status: VALIDATED

Source sequence(s)

AC110517, AC140339, CT010469
NM_001403360.1 → NP_001390289.1 tyrosine-protein kinase Fer isoform d

Status: VALIDATED

Source sequence(s)

AC110517, AC140339, CT010469
NM_001403361.1 → NP_001390290.1 tyrosine-protein kinase Fer isoform e

Status: VALIDATED

Source sequence(s)

AC110517, CT010469
NM_008000.2 → NP_032026.2 tyrosine-protein kinase Fer isoform b

See identical proteins and their annotated locations for NP_032026.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, and has multiple differences in the coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus and lacks an internal aa, compared to isoform a.

Source sequence(s)

BC058100, M32054

Consensus CDS

CCDS28937.1

UniProtKB/Swiss-Prot

P70451

Related

ENSMUSP00000037418.6, ENSMUST00000038080.7

Conserved Domains (3) summary

cd10361
Location:84 → 169

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

pfam07714
Location:194 → 445

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:197 → 447

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

64136945..64453515

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160314.1 → XP_036016207.1 tyrosine-protein kinase Fer isoform X1

UniProtKB/Swiss-Prot

P70451, Q61561, Q6PEE5, Q80UI3, Q8C481, Q9EQ77

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:454 → 539

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:567 → 817

PKc_like; Protein Kinases, catalytic domain
XM_006523641.5 → XP_006523704.1 tyrosine-protein kinase Fer isoform X1

See identical proteins and their annotated locations for XP_006523704.1

UniProtKB/Swiss-Prot

P70451, Q61561, Q6PEE5, Q80UI3, Q8C481, Q9EQ77

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:454 → 539

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:567 → 817

PKc_like; Protein Kinases, catalytic domain
XM_006523643.5 → XP_006523706.1 tyrosine-protein kinase Fer isoform X2

See identical proteins and their annotated locations for XP_006523706.1

UniProtKB/Swiss-Prot

P70451

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:453 → 538

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:566 → 816

PKc_like; Protein Kinases, catalytic domain
XM_006523645.5 → XP_006523708.1 tyrosine-protein kinase Fer isoform X3

Conserved Domains (3) summary

cd10361
Location:381 → 466

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl12013
Location:1 → 165

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21453
Location:494 → 744

PKc_like; Protein Kinases, catalytic domain
XM_006523650.5 → XP_006523713.1 tyrosine-protein kinase Fer isoform X6

UniProtKB/TrEMBL

Q3TME9

Conserved Domains (1) summary

cl12013
Location:5 → 238

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006523640.5 → XP_006523703.1 tyrosine-protein kinase Fer isoform X1

See identical proteins and their annotated locations for XP_006523703.1

UniProtKB/Swiss-Prot

P70451, Q61561, Q6PEE5, Q80UI3, Q8C481, Q9EQ77

Conserved Domains (3) summary

cd07686
Location:5 → 238

F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase

cd10361
Location:454 → 539

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:567 → 817

PKc_like; Protein Kinases, catalytic domain
XM_017317244.2 → XP_017172733.1 tyrosine-protein kinase Fer isoform X5

Conserved Domains (2) summary

cd10361
Location:65 → 150

SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins

cl21453
Location:178 → 428

PKc_like; Protein Kinases, catalytic domain