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    Zdhhc11 zinc finger, DHHC domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 71164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc11provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 11provided by MGI
    Primary source
    MGI:MGI:1918414
    See related
    Ensembl:ENSMUSG00000069189 AllianceGenome:MGI:1918414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHHC-11; Zdhhc20; 4933421L13Rik
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Located in endosome membrane. Is expressed in brain; male reproductive gland or organ; metanephros; and submandibular gland. Orthologous to several human genes including ZDHHC11B (zinc finger DHHC-type containing 11B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 13.3) See more
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    Genomic context

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    See Zdhhc11 in Genome Data Viewer
    Location:
    13 C1; 13 40.15 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74111970..74141109)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73963851..73992990)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 13 Neighboring gene predicted gene, 57611 Neighboring gene bromodomain containing 9 Neighboring gene predicted gene, 41002 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene 15912 Neighboring gene tubulin polymerization promoting protein Neighboring gene integrin linked kinase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization. Murakami Y, et al. Cancer Med, 2022 Oct. PMID 35384384, Free PMC Article
    2. ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†. Wu Y, et al. Biol Reprod, 2022 Mar 19. PMID 34897408
    3. ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization. Liu E, et al. Front Cell Dev Biol, 2021. PMID 34490261, Free PMC Article
    4. ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association. Liu Y, et al. Cell Mol Immunol, 2018 Oct. PMID 29429998, Free PMC Article
    5. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.
      Title: Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.
    2. Mechanistically, ZDHHC11 facilitated the optimal recruitment of IRF3 to MITA.
      Title: ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.
    3. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
      Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151180, MGC151184

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC11
    Names
    DHHC-containing protein 10
    DHHC10(z11)
    probable palmitoyltransferase ZDHHC11
    zinc finger DHHC domain-containing protein 11
    zinc finger, DHHC domain containing 20
    NP_081980.1
    XP_006517440.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027704.3 → NP_081980.1  palmitoyltransferase ZDHHC11

      See identical proteins and their annotated locations for NP_081980.1

      Status: VALIDATED

      Source sequence(s)
      AK016865, BB012497, BC116807
      Consensus CDS
      CCDS36729.1
      UniProtKB/Swiss-Prot
      Q14AK4, Q5Y5T4
      UniProtKB/TrEMBL
      A0A1Y7VLH9
      Related
      ENSMUSP00000089075.5, ENSMUST00000091493.6
      Conserved Domains (1) summary
      pfam01529
      Location:123 → 277
      zf-DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_153830.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT010471
      Related
      ENSMUST00000222487.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74111970..74141109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517377.4 → XP_006517440.1  palmitoyltransferase ZDHHC11 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:8 → 144
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14AK4.2 GenPept UniProtKB/Swiss-Prot:Q14AK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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