Slc47a2 solute carrier family 47, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc47a2provided by MGI
Official Full Name: solute carrier family 47, member 2provided by MGI
Primary source: MGI:MGI:3588190
See related: Ensembl:ENSMUSG00000069855 AllianceGenome:MGI:3588190
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933429E10Rik
Summary: Enables organic cation transmembrane transporter activity and polyspecific organic cation:proton antiporter activity. Involved in organic cation transport. Located in plasma membrane. Is expressed in Harderian gland; esophagus; male reproductive gland or organ; and skin. Orthologous to human SLC47A1 (solute carrier family 47 member 1) and SLC47A2 (solute carrier family 47 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 31.6) and ovary adult (RPKM 5.0) See more
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61192453..61233686, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61301627..61342860, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MATE2 mRNA expression levels were the highest in the testis, where high expression was localized to Sertoli cells, a critical cell type of the blood testis barrier.
Title: Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice.
testes-specific multidrug and toxic compound extrusion 2 (MATE2) act as a polyspecific H(+)/organic cation exporter in Leydig cells.
Title: Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter.
The purpose of this study was to evaluate the effects of heterozygous MATE variants on the disposition of metformin in mice and humans.
Title: Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

Slc47a2 (e-PCR), detects polymorphism
- UniSTS:547121

AI036982 (e-PCR)
- UniSTS:165762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables polyspecific organic cation:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables polyspecific organic cation:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thiamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in organic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multidrug and toxin extrusion protein 2

Names: MATE-2; h(+)/organic cation antiporter kidney-specific; mMATE-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033542.2 → NP_001028714.1 multidrug and toxin extrusion protein 2

See identical proteins and their annotated locations for NP_001028714.1

Status: PROVISIONAL

Source sequence(s)

AK133432

Consensus CDS

CCDS24810.1

UniProtKB/Swiss-Prot

B2RXN1, Q3V050, Q5SS46

UniProtKB/TrEMBL

Z4YMV2

Related

ENSMUSP00000090710.3, ENSMUST00000093029.9

Conserved Domains (2) summary

COG0534
Location:36 → 479

NorM; Na+-driven multidrug efflux pump [Defense mechanisms]

cd13132
Location:43 → 477

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61192453..61233686 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533616.1 → XP_006533679.1 multidrug and toxin extrusion protein 2 isoform X1

Conserved Domains (1) summary

cd13132
Location:1 → 369

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family