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    Csmd1 CUB and Sushi multiple domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 94109, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csmd1provided by MGI
    Official Full Name
    CUB and Sushi multiple domains 1provided by MGI
    Primary source
    MGI:MGI:2137383
    See related
    Ensembl:ENSMUSG00000060924 AllianceGenome:MGI:2137383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1890; B930082H09
    Summary
    Acts upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Predicted to be located in membrane. Is expressed in nervous system. Used to study schizophrenia. Orthologous to human CSMD1 (CUB and Sushi multiple domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.0), frontal lobe adult (RPKM 1.5) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Csmd1 in Genome Data Viewer
    Location:
    8 A1.1- A1.3; 8 8.38 cM
    Exon count:
    71
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (15942538..17586908, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (15892538..17535385, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20808 Neighboring gene STARR-seq mESC enhancer starr_20809 Neighboring gene STARR-seq mESC enhancer starr_20810 Neighboring gene predicted gene, 46033 Neighboring gene STARR-seq mESC enhancer starr_20813 Neighboring gene STARR-seq mESC enhancer starr_20814 Neighboring gene chromobox 1 pseudogene Neighboring gene predicted gene, 46073 Neighboring gene microRNA 3106 Neighboring gene predicted gene, 53402 Neighboring gene STARR-seq mESC enhancer starr_20815 Neighboring gene predicted gene 16347 Neighboring gene predicted gene, 18319 Neighboring gene predicted gene, 25278 Neighboring gene STARR-seq mESC enhancer starr_20817 Neighboring gene STARR-seq mESC enhancer starr_20818 Neighboring gene STARR-seq mESC enhancer starr_20819 Neighboring gene predicted gene, 39136 Neighboring gene STARR-seq mESC enhancer starr_20820 Neighboring gene STARR-seq mESC enhancer starr_20821 Neighboring gene STARR-seq mESC enhancer starr_20822 Neighboring gene predicted gene, 39137 Neighboring gene STARR-seq mESC enhancer starr_20825 Neighboring gene STARR-seq mESC enhancer starr_20828 Neighboring gene STARR-seq mESC enhancer starr_20829 Neighboring gene heat shock protein 1 (chaperonin) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Clone Names

    • KIAA1890

    General protein information

    Preferred Names
    CUB and sushi domain-containing protein 1
    Names
    CUB and sushi multiple domains protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053171.2NP_444401.2  CUB and sushi domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_444401.2

      Status: VALIDATED

      Source sequence(s)
      AC101229, AC154107, AK081081, AK134585, AK220429, AY017475
      Consensus CDS
      CCDS40244.1
      UniProtKB/Swiss-Prot
      E9QK23, Q8BUV1, Q8BYQ3, Q923L3
      Related
      ENSMUSP00000080751.7, ENSMUST00000082104.7
      Conserved Domains (5) summary
      cd00033
      Location:26802734
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:20872142
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:26192855
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:758865
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:29783032
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      15942538..17586908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508931.5XP_006508994.2  CUB and sushi domain-containing protein 1 isoform X2

      Conserved Domains (4) summary
      cd00033
      Location:563617
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:21232178
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:26552891
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:794901
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    2. XM_036154398.1XP_036010291.1  CUB and sushi domain-containing protein 1 isoform X1

      Conserved Domains (4) summary
      cd00033
      Location:563617
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:21232178
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:26552891
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:794901
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    3. XM_030243874.1XP_030099734.1  CUB and sushi domain-containing protein 1 isoform X4

      Conserved Domains (6) summary
      cd00033
      Location:16811734
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:909964
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:14411677
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:273378
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:10801137
      Sushi; Sushi repeat (SCR repeat)
      cl00049
      Location:433
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    4. XM_036154399.1XP_036010292.1  CUB and sushi domain-containing protein 1 isoform X3

      Conserved Domains (4) summary
      cd00033
      Location:563617
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:21232178
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:24882653
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:794901
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.