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    Chd1l chromodomain helicase DNA binding protein 1-like [ Mus musculus (house mouse) ]

    Gene ID: 68058, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chd1lprovided by MGI
    Official Full Name
    chromodomain helicase DNA binding protein 1-likeprovided by MGI
    Primary source
    MGI:MGI:1915308
    See related
    Ensembl:ENSMUSG00000028089 AllianceGenome:MGI:1915308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Alc1; Snf2p; 4432404A22Rik
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; histone reader activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Predicted to be involved in DNA repair and chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus and site of double-strand break. Is expressed in genitourinary system and liver. Orthologous to human CHD1L (chromodomain helicase DNA binding protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 13.9), bladder adult (RPKM 9.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Chd1l in Genome Data Viewer
    Location:
    3 F2.2; 3 42.17 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97468056..97517538, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97560740..97610222, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40101 Neighboring gene olfactory receptor family 13 subfamily L member 2 Neighboring gene STARR-seq mESC enhancer starr_08465 Neighboring gene STARR-seq mESC enhancer starr_08467 Neighboring gene STARR-seq mESC enhancer starr_08468 Neighboring gene predicted gene, 40102 Neighboring gene flavin containing monooxygenase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene protein kinase, AMP-activated, beta 2 non-catalytic subunit Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent chromatin remodeler activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent chromatin remodeler activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables poly-ADP-D-ribose modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly-ADP-D-ribose modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    chromodomain-helicase-DNA-binding protein 1-like
    Names
    amplified in liver cancer 1
    NP_001405749.1
    NP_080815.1
    XP_017175190.1
    XP_036019152.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418820.1NP_001405749.1  chromodomain-helicase-DNA-binding protein 1-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140839
    2. NM_026539.3NP_080815.1  chromodomain-helicase-DNA-binding protein 1-like isoform 1

      See identical proteins and their annotated locations for NP_080815.1

      Status: VALIDATED

      Source sequence(s)
      AC140839
      Consensus CDS
      CCDS38561.1
      UniProtKB/Swiss-Prot
      Q3TMX1, Q6P5C0, Q9CXF7
      Related
      ENSMUSP00000029730.5, ENSMUST00000029730.5
      Conserved Domains (4) summary
      cd00046
      Location:59199
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd03331
      Location:721871
      Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
      pfam00176
      Location:43322
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:340453
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      97468056..97517538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163259.1XP_036019152.1  chromodomain-helicase-DNA-binding protein 1-like isoform X3

      Conserved Domains (1) summary
      PLN03142
      Location:39549
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    2. XM_017319701.3XP_017175190.1  chromodomain-helicase-DNA-binding protein 1-like isoform X2

      Conserved Domains (1) summary
      PLN03142
      Location:39549
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional