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    Timm21 translocase of inner mitochondrial membrane 21 [ Mus musculus (house mouse) ]

    Gene ID: 67105, updated on 9-Dec-2024

    Summary

    Official Symbol
    Timm21provided by MGI
    Official Full Name
    translocase of inner mitochondrial membrane 21provided by MGI
    Primary source
    MGI:MGI:1920595
    See related
    Ensembl:ENSMUSG00000024645 AllianceGenome:MGI:1920595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700034H14Rik; 2700002I20Rik
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly; and protein import into mitochondrial matrix. Located in mitochondrion. Orthologous to human TIMM21 (translocase of inner mitochondrial membrane 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.4), limb E14.5 (RPKM 10.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Timm21 in Genome Data Viewer
    Location:
    18 E4; 18 57.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84964316..84970168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84946191..84951530, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45257 Neighboring gene STARR-positive B cell enhancer ABC_E8728 Neighboring gene predicted gene, 17266 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:85043680-85043998 Neighboring gene STARR-seq mESC enhancer starr_45258 Neighboring gene predicted gene 16146 Neighboring gene STARR-positive B cell enhancer ABC_E11009 Neighboring gene STARR-seq mESC enhancer starr_45265 Neighboring gene cytochrome b5 type A (microsomal) Neighboring gene STARR-seq mESC enhancer starr_45275 Neighboring gene F-box protein 15 Neighboring gene STARR-seq mESC enhancer starr_45276 Neighboring gene STARR-seq mESC enhancer starr_45277 Neighboring gene STARR-seq mESC enhancer starr_45279 Neighboring gene predicted gene, 32291 Neighboring gene predicted gene 7612

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim21
    Names
    TIM21-like protein, mitochondrial
    tranlocase of inner mitochondrial membrane 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025969.5NP_080245.1  mitochondrial import inner membrane translocase subunit Tim21

      See identical proteins and their annotated locations for NP_080245.1

      Status: VALIDATED

      Source sequence(s)
      AC134545
      Consensus CDS
      CCDS29386.1
      UniProtKB/Swiss-Prot
      Q3THX0, Q8CCM6, Q8CE44, Q9CYU8, Q9CZS4
      Related
      ENSMUSP00000025547.3, ENSMUST00000025547.4
      Conserved Domains (1) summary
      pfam08294
      Location:98240
      TIM21

    RNA

    1. NR_160856.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134545

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      84964316..84970168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247094.4XP_011245396.1  mitochondrial import inner membrane translocase subunit Tim21 isoform X1

      See identical proteins and their annotated locations for XP_011245396.1

      UniProtKB/Swiss-Prot
      Q8CCM6
      Conserved Domains (1) summary
      cl21648
      Location:98167
      Coa1; Cytochrome oxidase complex assembly protein 1