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    G3bp2 G3BP stress granule assembly factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 23881, updated on 9-Dec-2024

    Summary

    Official Symbol
    G3bp2provided by MGI
    Official Full Name
    G3BP stress granule assembly factor 2provided by MGI
    Primary source
    MGI:MGI:2442040
    See related
    Ensembl:ENSMUSG00000029405 AllianceGenome:MGI:2442040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G3BP; mKIAA0660; E430034L04Rik
    Summary
    Predicted to enable mRNA binding activity and molecular condensate scaffold activity. Predicted to be involved in positive regulation of stress granule assembly; protein homooligomerization; and stress granule assembly. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in several structures, including central nervous system; ovary; sensory organ; and tooth. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 38.0), whole brain E14.5 (RPKM 34.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See G3bp2 in Genome Data Viewer
    Location:
    5 E2; 5 45.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92200004..92285584, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92052145..92137725, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13624 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cyclin dependent kinase like 2 Neighboring gene predicted gene, 46915 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92471665-92471966 Neighboring gene predicted gene, 22728 Neighboring gene predicted gene, 42111 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92512687-92512988 Neighboring gene predicted gene, 46933 Neighboring gene STARR-seq mESC enhancer starr_13632 Neighboring gene uncharacterized LOC105246914 Neighboring gene STARR-seq mESC enhancer starr_13633 Neighboring gene STARR-positive B cell enhancer ABC_E11293 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene USO1 vesicle docking factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92612573-92612756 Neighboring gene predicted gene, 25290

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular condensate scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress granule assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein-binding protein 2
    Names
    GTPase activating protein (SH3 domain) binding protein 2
    Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080794.2NP_001074263.1  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_001074263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK153221, AK169571, BY578810, CN527272
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379, Q3UL55, Q9R1B8
      UniProtKB/TrEMBL
      Q3U541, Q3U931
      Related
      ENSMUSP00000128244.2, ENSMUST00000169094.8
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    2. NM_001080795.2NP_001074264.1  ras GTPase-activating protein-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_001074264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
      Source sequence(s)
      AK076117, AK169571, BY272229, BY578810
      Consensus CDS
      CCDS39149.1
      UniProtKB/TrEMBL
      Q3U931, Q542W3
      Related
      ENSMUSP00000108752.4, ENSMUST00000113127.7
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293375
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    3. NM_001080796.2NP_001074265.1  ras GTPase-activating protein-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_001074265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
      Source sequence(s)
      AK151732, AK169571, BY578810, CN527272
      Consensus CDS
      CCDS39149.1
      UniProtKB/TrEMBL
      Q3U931, Q542W3
      Related
      ENSMUSP00000132469.2, ENSMUST00000167918.8
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293375
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    4. NM_001080797.2NP_001074266.1  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_001074266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK149427, AK169571, BY578810
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379, Q3UL55, Q9R1B8
      UniProtKB/TrEMBL
      Q3U541, Q3U931
      Related
      ENSMUSP00000128353.2, ENSMUST00000164378.8
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    5. NM_001359195.1NP_001346124.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AC122438, AC165433
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379, Q3UL55, Q9R1B8
      UniProtKB/TrEMBL
      Q3U541, Q3U931
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    6. NM_001359196.1NP_001346125.1  ras GTPase-activating protein-binding protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AC122438, AC165433
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379, Q3UL55, Q9R1B8
      UniProtKB/TrEMBL
      Q3U541, Q3U931
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    7. NM_001359197.1NP_001346126.1  ras GTPase-activating protein-binding protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
      Source sequence(s)
      AC122438, AC165433
      Consensus CDS
      CCDS39149.1
      UniProtKB/TrEMBL
      Q3U931, Q542W3
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293375
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
    8. NM_011816.4NP_035946.2  ras GTPase-activating protein-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_035946.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK145697, AK169571, BY272229, BY578810
      Consensus CDS
      CCDS19427.1
      UniProtKB/Swiss-Prot
      P97379, Q3UL55, Q9R1B8
      UniProtKB/TrEMBL
      Q3U541, Q3U931
      Related
      ENSMUSP00000144456.2, ENSMUST00000202258.4
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:326408
      RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92200004..92285584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254467.1XP_030110327.1  ras GTPase-activating protein-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3U931, Q542W3
      Conserved Domains (2) summary
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12464
      Location:293375
      RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins