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    Tnip1 TNFAIP3 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 57783, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnip1provided by MGI
    Official Full Name
    TNFAIP3 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1926194
    See related
    Ensembl:ENSMUSG00000020400 AllianceGenome:MGI:1926194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nef; VAN; ABIN; Naf1; ABIN1; ABIN-1
    Summary
    Enables polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of canonical NF-kappaB signal transduction; positive regulation of defense response; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 26.8), duodenum adult (RPKM 23.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnip1 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54801613..54853766, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54910787..54962956, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1343 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene glutathione peroxidase 3 Neighboring gene STARR-positive B cell enhancer ABC_E11481 Neighboring gene STARR-positive B cell enhancer ABC_E1824 Neighboring gene 40S ribosomal protein S11-like Neighboring gene STARR-seq mESC enhancer starr_29522 Neighboring gene STARR-seq mESC enhancer starr_29523 Neighboring gene annexin A6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54836566-54836859 Neighboring gene predicted gene, 19911 Neighboring gene coiled-coil domain containing 69

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MyD88-dependent toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TNFAIP3-interacting protein 1
    Names
    A20-binding inhibitor of NF-kappa B activation
    Nef-associated factor 1
    virion-associated nuclear shuttling protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199275.2NP_001186204.1  TNFAIP3-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001186204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AL593846
      Consensus CDS
      CCDS24704.1
      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      UniProtKB/TrEMBL
      E9QM75
      Related
      ENSMUSP00000099792.2, ENSMUST00000102731.8
      Conserved Domains (2) summary
      COG1196
      Location:311542
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:227264
      MreC; rod shape-determining protein MreC
    2. NM_001199276.2NP_001186205.1  TNFAIP3-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001186205.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AL593846
      Consensus CDS
      CCDS56769.1
      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Related
      ENSMUSP00000104514.2, ENSMUST00000108886.8
      Conserved Domains (2) summary
      COG1196
      Location:258489
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:174211
      MreC; rod shape-determining protein MreC
    3. NM_001271455.1NP_001258384.1  TNFAIP3-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001258384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AL593846
      Consensus CDS
      CCDS56769.1
      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Related
      ENSMUSP00000104513.2, ENSMUST00000108885.8
      Conserved Domains (2) summary
      COG1196
      Location:258489
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:174211
      MreC; rod shape-determining protein MreC
    4. NM_001271456.1NP_001258385.1  TNFAIP3-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001258385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL593846
      Consensus CDS
      CCDS70188.1
      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      UniProtKB/TrEMBL
      D3Z2W0
      Related
      ENSMUSP00000099791.3, ENSMUST00000102730.9
      Conserved Domains (2) summary
      COG1196
      Location:311542
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:227264
      MreC; rod shape-determining protein MreC
    5. NM_021327.4NP_067302.2  TNFAIP3-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_067302.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AL593846
      Consensus CDS
      CCDS24704.1
      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      UniProtKB/TrEMBL
      E9QM75
      Related
      ENSMUSP00000018482.7, ENSMUST00000018482.13
      Conserved Domains (2) summary
      COG1196
      Location:311542
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:227264
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54801613..54853766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249162.1XP_011247464.1  TNFAIP3-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011247464.1

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      UniProtKB/TrEMBL
      D3Z2W0
      Conserved Domains (2) summary
      COG1196
      Location:311542
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:227264
      MreC; rod shape-determining protein MreC
    2. XM_030246197.2XP_030102057.1  TNFAIP3-interacting protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Conserved Domains (2) summary
      COG1196
      Location:258489
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:174211
      MreC; rod shape-determining protein MreC
    3. XM_011249163.4XP_011247465.1  TNFAIP3-interacting protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011247465.1

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Conserved Domains (2) summary
      COG1196
      Location:258489
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:174211
      MreC; rod shape-determining protein MreC
    4. XM_030246199.1XP_030102059.1  TNFAIP3-interacting protein 1 isoform X6

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Conserved Domains (2) summary
      COG1196
      Location:225456
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:141178
      MreC; rod shape-determining protein MreC
    5. XM_006533848.3XP_006533911.1  TNFAIP3-interacting protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006533911.1

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Conserved Domains (2) summary
      COG1196
      Location:225456
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:141178
      MreC; rod shape-determining protein MreC
    6. XM_011249164.3XP_011247466.1  TNFAIP3-interacting protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011247466.1

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Conserved Domains (2) summary
      COG1196
      Location:225456
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:141178
      MreC; rod shape-determining protein MreC
    7. XM_006533847.5XP_006533910.1  TNFAIP3-interacting protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006533910.1

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      Conserved Domains (2) summary
      COG1196
      Location:258489
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:174211
      MreC; rod shape-determining protein MreC
    8. XM_030246196.2XP_030102056.1  TNFAIP3-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      UniProtKB/TrEMBL
      D3Z2W0
      Conserved Domains (2) summary
      COG1196
      Location:311542
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:227264
      MreC; rod shape-determining protein MreC
    9. XM_006533846.5XP_006533909.1  TNFAIP3-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006533909.1

      UniProtKB/Swiss-Prot
      Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8
      UniProtKB/TrEMBL
      E9QM75
      Related
      ENSMUSP00000104517.4, ENSMUST00000108889.10
      Conserved Domains (2) summary
      COG1196
      Location:311542
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19252
      Location:227264
      MreC; rod shape-determining protein MreC