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    Irx2 Iroquois homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 16372, updated on 9-Dec-2024

    Summary

    Official Symbol
    Irx2provided by MGI
    Official Full Name
    Iroquois homeobox 2provided by MGI
    Primary source
    MGI:MGI:1197526
    See related
    Ensembl:ENSMUSG00000001504 AllianceGenome:MGI:1197526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in proximal/distal pattern formation involved in metanephric nephron development and specification of loop of Henle identity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and respiratory system. Orthologous to human IRX2 (iroquois homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 35.9), mammary gland adult (RPKM 23.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Irx2 in Genome Data Viewer
    Location:
    13 C1; 13 39.23 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (72771463..72782315)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (72624430..72634196)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41000 Neighboring gene predicted gene, 38580 Neighboring gene STARR-seq mESC enhancer starr_34980 Neighboring gene predicted gene, 20554 Neighboring gene predicted gene, 41001 Neighboring gene RIKEN cDNA D730050B12 gene Neighboring gene STARR-seq mESC enhancer starr_34983

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103290

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    iroquois-class homeodomain protein IRX-2
    Names
    Iroquois related homeobox 2
    homeodomain protein IRXA2
    iroquois homeobox protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010574.4NP_034704.1  iroquois-class homeodomain protein IRX-2

      See identical proteins and their annotated locations for NP_034704.1

      Status: VALIDATED

      Source sequence(s)
      AK018266, AK148520, CT030229
      Consensus CDS
      CCDS26628.1
      UniProtKB/Swiss-Prot
      O55121, P81066, Q3UFG3, Q9ERN1, Q9JLL4
      Related
      ENSMUSP00000073976.5, ENSMUST00000074372.6
      Conserved Domains (3) summary
      smart00548
      Location:325342
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      COG5576
      Location:115217
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam05920
      Location:133172
      Homeobox_KN; Homeobox KN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      72771463..72782315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247164.2XP_030103024.1  iroquois-class homeodomain protein IRX-2 isoform X1

      Conserved Domains (3) summary
      smart00548
      Location:231248
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      COG5576
      Location:21123
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam05920
      Location:3978
      Homeobox_KN; Homeobox KN domain