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    SNHG8 small nucleolar RNA host gene 8 [ Homo sapiens (human) ]

    Gene ID: 100093630, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SNHG8provided by HGNC
    Official Full Name
    small nucleolar RNA host gene 8provided by HGNC
    Primary source
    HGNC:HGNC:33098
    See related
    Ensembl:ENSG00000269893 AllianceGenome:HGNC:33098
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00060; NCRNA00060
    Expression
    Ubiquitous expression in ovary (RPKM 73.3), prostate (RPKM 50.6) and 25 other tissues See more
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    Genomic context

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    See SNHG8 in Genome Data Viewer
    Location:
    4q26
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (118278762..118279823)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (121583738..121584799)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (119199917..119200978)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986307 Neighboring gene N-deacetylase and N-sulfotransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:119115072-119115572 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:119115573-119116073 Neighboring gene FKBP prolyl isomerase 4 pseudogene 1 Neighboring gene uncharacterized LOC105377392 Neighboring gene uncharacterized LOC124900765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15649 Neighboring gene uncharacterized LOC124900766 Neighboring gene small nucleolar RNA, H/ACA box 24 Neighboring gene serine protease 12 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:119273903-119274748 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:119318395-119319594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21846 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression. Huang T, et al. Oncotarget, 2016 Dec 6. PMID 27835598, Free PMC Article
    2. lncRNA SNHG8 promotes aggressive behaviors of nasopharyngeal carcinoma via regulating miR-656-3p/SATB1 axis. Tian X, et al. Biomed Pharmacother, 2020 Nov. PMID 32920509
    3. Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7. Shi Z, et al. J Gene Med, 2021 Mar. PMID 33450101
    4. Small nucleolar RNA host gene 8: A rising star in the targets for cancer therapy. Yuan X, et al. Biomed Pharmacother, 2021 Jul. PMID 33894626
    5. LncRNA SNHG8 accelerates proliferation and inhibits apoptosis in HPV-induced cervical cancer through recruiting EZH2 to epigenetically silence RECK expression. Qu X, et al. J Cell Biochem, 2020 Oct. PMID 31961005

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
      Title: Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
    2. The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
      Title: The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
    3. LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK1/2 signaling axis.
      Title: LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK(1/2) signaling axis.
    4. A review on the role of SNHG8 in human disorders.
      Title: A review on the role of SNHG8 in human disorders.
    5. [Matrix stiffening related lncRNA SNHG8 regulates chemosensitivity of ovarian cancer].
      Title: [Matrix stiffening related lncRNA SNHG8 regulates chemosensitivity of ovarian cancer].
    6. Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
      Title: Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
    7. YY1-induced long non-coding RNA small nucleolar RNA host gene 8 promotes the tumorigenesis of melanoma via the microRNA-656-3p/SERPINE1 mRNA binding protein 1 axis.
      Title: YY1-induced long non-coding RNA small nucleolar RNA host gene 8 promotes the tumorigenesis of melanoma via the microRNA-656-3p/SERPINE1 mRNA binding protein 1 axis.
    8. SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis.
      Title: SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis.
    9. Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis.
      Title: Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis.
    10. Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.
      Title: Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • long intergenic non-protein coding RNA 60
    • small nucleolar RNA host gene (non-protein coding) 8
    • small nucleolar RNA host gene 8 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003584.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      BC039555, CF124302
      Related
      ENST00000729030.1

    2. NR_034010.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment compared to variant 1.
      Source sequence(s)
      BC039555, BM845860
      Related
      ENST00000729036.1

    3. NR_034011.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment compared to variant 1.
      Source sequence(s)
      BC039555, CD520851
      Related
      ENST00000729037.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      118278762..118279823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      121583738..121584799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials