IRAK4 interleukin 1 receptor associated kinase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IRAK4provided by HGNC
Official Full Name: interleukin 1 receptor associated kinase 4provided by HGNC
Primary source: HGNC:HGNC:17967
See related: Ensembl:ENSG00000198001 MIM:606883; AllianceGenome:HGNC:17967
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IPD1; IMD67; REN64; IRAK-4; NY-REN-64
Summary: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in lymph node (RPKM 7.4), appendix (RPKM 6.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (43758951..43789541)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (43717649..43748266)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (44152754..44183344)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension.
Title: Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension.
Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4.
Title: Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4.
Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.
Title: Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML.
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia.
Title: Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia.
Pseudomonas Meningitis and Intracranial Hemorrhage in IRAK-4 Deficiency.
Title: Pseudomonas Meningitis and Intracranial Hemorrhage in IRAK-4 Deficiency.
IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma.
Title: IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in Pancreatic Ductal Adenocarcinoma.
Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children.
Title: Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children.
IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants.
Title: IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants.
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
Title: Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance.
Title: Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 67 MedGen: C1843256 OMIM: 607676 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:313261 (e-PCR)
- UniSTS:156445

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

IRAK4__6475 (e-PCR)
- UniSTS:464504

D11S3114 (e-PCR)
- UniSTS:152207

D16S325 (e-PCR)
- UniSTS:147089

RH26210 (e-PCR)
- UniSTS:86451

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MyD88-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in interleukin-1-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-1-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in interleukin-33-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	IC Inferred by Curator more info	PubMed
involved_in toll-like receptor 9 signaling pathway	TAS Traceable Author Statement more info
involved_in toll-like receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome membrane	TAS Traceable Author Statement more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of plasma membrane	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase 4

Names: renal carcinoma antigen NY-REN-64

NP_001107654.1

EC 2.7.11.1

NP_001138728.1

EC 2.7.11.1

NP_001138729.1

EC 2.7.11.1

NP_001138730.1

EC 2.7.11.1

NP_001338267.1

EC 2.7.11.1

NP_001338268.1

EC 2.7.11.1

NP_001338269.1

EC 2.7.11.1

NP_001338270.1

EC 2.7.11.1

NP_001338271.1

EC 2.7.11.1

NP_001338272.1

EC 2.7.11.1

NP_001338273.1

EC 2.7.11.1

NP_001338274.1

EC 2.7.11.1

NP_057207.2

EC 2.7.11.1

XP_005269000.1

EC 2.7.11.1

XP_005269001.1

EC 2.7.11.1

XP_005269002.1

EC 2.7.11.1

XP_006719501.1

EC 2.7.11.1

XP_011536733.1

EC 2.7.11.1

XP_016874879.1

EC 2.7.11.1

XP_054228149.1

EC 2.7.11.1

XP_054228150.1

EC 2.7.11.1

XP_054228151.1

EC 2.7.11.1

XP_054228152.1

EC 2.7.11.1

XP_054228153.1

EC 2.7.11.1

XP_054228154.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009892.1 RefSeqGene

Range

5001..35600

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_75

mRNA and Protein(s)

NM_001114182.3 → NP_001107654.1 interleukin-1 receptor-associated kinase 4 isoform a

See identical proteins and their annotated locations for NP_001107654.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 13 all encode the same isoform (a).

Source sequence(s)

AC093012, AI126481, AK304583, AY340963

Consensus CDS

CCDS8744.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Related

ENSP00000446490.1, ENST00000551736.5

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001145256.2 → NP_001138728.1 interleukin-1 receptor-associated kinase 4 isoform b

See identical proteins and their annotated locations for NP_001138728.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate exon and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3-10 all encode the same isoform (b).

Source sequence(s)

AC093012, AI126481, AK304583, AY340965

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001145257.2 → NP_001138729.1 interleukin-1 receptor-associated kinase 4 isoform b

See identical proteins and their annotated locations for NP_001138729.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3-10 all encode the same isoform (b).

Source sequence(s)

AC093012, AI126481, AK299944

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001145258.2 → NP_001138730.1 interleukin-1 receptor-associated kinase 4 isoform b

See identical proteins and their annotated locations for NP_001138730.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks three alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (b), also known as the short form, has a shorter N-terminus, compared to isoform a. Variants 3-10 all encode the same isoform (b).

Source sequence(s)

AC093012, AI126481, AK304583

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Related

ENSP00000408734.2, ENST00000440781.6

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001351338.2 → NP_001338267.1 interleukin-1 receptor-associated kinase 4 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 3-5 and 7-10, encodes isoform b.

Source sequence(s)

AC093012, AK027301

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001351339.2 → NP_001338268.1 interleukin-1 receptor-associated kinase 4 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 3-6 and 8-10, encodes isoform b.

Source sequence(s)

AC093012, AY340967

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001351340.2 → NP_001338269.1 interleukin-1 receptor-associated kinase 4 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variants 3-7, 9, and 10, encodes isoform b.

Source sequence(s)

AC093012

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001351341.2 → NP_001338270.1 interleukin-1 receptor-associated kinase 4 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 3-8 and 10, encodes isoform b.

Source sequence(s)

AC093012

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001351342.2 → NP_001338271.1 interleukin-1 receptor-associated kinase 4 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 3-9, encodes isoform b.

Source sequence(s)

AC093012

Consensus CDS

CCDS44862.1

UniProtKB/TrEMBL

B4E359

Conserved Domains (1) summary

cd14158
Location:46 → 333

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_001351343.2 → NP_001338272.1 interleukin-1 receptor-associated kinase 4 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variant 12, encodes isoform c.

Source sequence(s)

AC093012

Conserved Domains (1) summary

cl21453
Location:12 → 254

PKc_like; Protein Kinases, catalytic domain
NM_001351344.2 → NP_001338273.1 interleukin-1 receptor-associated kinase 4 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variant 11, encodes isoform c.

Source sequence(s)

AC093012

Conserved Domains (1) summary

cl21453
Location:12 → 254

PKc_like; Protein Kinases, catalytic domain
NM_001351345.2 → NP_001338274.1 interleukin-1 receptor-associated kinase 4 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 1 and 2, encodes isoform a.

Source sequence(s)

AC093012

Consensus CDS

CCDS8744.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
NM_016123.4 → NP_057207.2 interleukin-1 receptor-associated kinase 4 isoform a

See identical proteins and their annotated locations for NP_057207.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 13 all encode the same isoform (a).

Source sequence(s)

AC093012, AI126481, AK304583, AK314288, BC013316

Consensus CDS

CCDS8744.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Related

ENSP00000479889.3, ENST00000613694.5

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

43758951..43789541

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011538431.3 → XP_011536733.1 interleukin-1 receptor-associated kinase 4 isoform X1

See identical proteins and their annotated locations for XP_011536733.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
XM_006719438.4 → XP_006719501.1 interleukin-1 receptor-associated kinase 4 isoform X1

See identical proteins and their annotated locations for XP_006719501.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
XM_005268945.5 → XP_005269002.1 interleukin-1 receptor-associated kinase 4 isoform X1

See identical proteins and their annotated locations for XP_005269002.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
XM_005268943.4 → XP_005269000.1 interleukin-1 receptor-associated kinase 4 isoform X1

See identical proteins and their annotated locations for XP_005269000.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
XM_017019390.3 → XP_016874879.1 interleukin-1 receptor-associated kinase 4 isoform X1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
XM_005268944.5 → XP_005269001.1 interleukin-1 receptor-associated kinase 4 isoform X1

See identical proteins and their annotated locations for XP_005269001.1

UniProtKB/Swiss-Prot

Q69FE1, Q8TDF7, Q9NWZ3, Q9Y589

UniProtKB/TrEMBL

B2RAP9, Q69FE3

Conserved Domains (2) summary

cd08793
Location:9 → 106

Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

cd14158
Location:170 → 457

STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

43717649..43748266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372174.1 → XP_054228149.1 interleukin-1 receptor-associated kinase 4 isoform X1

UniProtKB/TrEMBL

B2RAP9
XM_054372177.1 → XP_054228152.1 interleukin-1 receptor-associated kinase 4 isoform X1

UniProtKB/TrEMBL

B2RAP9
XM_054372176.1 → XP_054228151.1 interleukin-1 receptor-associated kinase 4 isoform X1

UniProtKB/TrEMBL

B2RAP9
XM_054372178.1 → XP_054228153.1 interleukin-1 receptor-associated kinase 4 isoform X1

UniProtKB/TrEMBL

B2RAP9
XM_054372175.1 → XP_054228150.1 interleukin-1 receptor-associated kinase 4 isoform X1

UniProtKB/TrEMBL

B2RAP9
XM_054372179.1 → XP_054228154.1 interleukin-1 receptor-associated kinase 4 isoform X1

UniProtKB/TrEMBL

B2RAP9