U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TRIM49 tripartite motif containing 49 [ Homo sapiens (human) ]

    Gene ID: 57093, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TRIM49provided by HGNC
    Official Full Name
    tripartite motif containing 49provided by HGNC
    Primary source
    HGNC:HGNC:13431
    See related
    Ensembl:ENSG00000168930 MIM:606124; AllianceGenome:HGNC:13431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF18; TRIM49A; TRIM49L2
    Summary
    The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010]
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TRIM49 in Genome Data Viewer
    Location:
    11q14.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89766451..89808575, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89717331..89728251, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89530823..89541743, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cell adhesion associated, oncogene regulated pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89477010-89477565 Neighboring gene UBTF like 2 (pseudogene) Neighboring gene tripartite motif containing 64D, pseudogene Neighboring gene ANKRD33B pseudogene 7 Neighboring gene tripartite motif containing 64B pseudogene Neighboring gene tripartite motif containing 53B, pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach(1). Yoshikawa T, et al. Biochim Biophys Acta, 2000 Oct 2. PMID 11018261
    2. Expression, purification, and characterization of the TRIM49 protein. Guimarães DS, et al. Protein Expr Purif, 2018 Mar. PMID 29107100
    3. Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination. Tikoo S, et al. EMBO J, 2013 Jun 12. PMID 23708797, Free PMC Article
    4. Identification of a genomic reservoir for new TRIM genes in primate genomes. Han K, et al. PLoS Genet, 2011 Dec. PMID 22144910, Free PMC Article
    5. TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Chauhan S, et al. Dev Cell, 2016 Oct 10. PMID 27693506, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tripartite motif-containing protein 49
    Names
    ring finger protein 18
    testis-specific RING Finger protein
    testis-specific ring-finger protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020358.2 → NP_065091.1  tripartite motif-containing protein 49

      See identical proteins and their annotated locations for NP_065091.1

      Status: REVIEWED

      Source sequence(s)
      AP004833
      Consensus CDS
      CCDS8287.1
      UniProtKB/Swiss-Prot
      P0CI25
      Related
      ENSP00000327604.1, ENST00000329758.5
      Conserved Domains (2) summary
      cd16603
      Location:12 → 57
      RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
      cl02614
      Location:285 → 448
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      89766451..89808575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448617.2 → XP_024304385.1  tripartite motif-containing protein 49 isoform X1

      Conserved Domains (2) summary
      cd16603
      Location:12 → 57
      RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
      cl02614
      Location:285 → 441
      SPRY; SPRY domain

    2. XM_017018027.3 → XP_016873516.1  tripartite motif-containing protein 49 isoform X2

      UniProtKB/TrEMBL
      E9PK69
      Related
      ENSP00000431618.2, ENST00000532501.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      89717331..89728251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369444.1 → XP_054225419.1  tripartite motif-containing protein 49 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CI25.1 GenPept UniProtKB/Swiss-Prot:P0CI25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools