LRRC25 leucine rich repeat containing 25 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LRRC25provided by HGNC
Official Full Name: leucine rich repeat containing 25provided by HGNC
Primary source: HGNC:HGNC:29806
See related: Ensembl:ENSG00000175489 MIM:607518; AllianceGenome:HGNC:29806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAPA
Summary: Located in cytosol; endoplasmic reticulum; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in spleen (RPKM 16.6), bone marrow (RPKM 11.9) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (18391137..18397622, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (18525309..18531805, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (18501947..18508432, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRC25, a potential leukocyte differentiation antigen, is a key regulator of all-trans retinoic acid-induced granulocytic differentiation
Title: LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen.
Our study has not only identified LRRC25 as a novel inhibitor of NF-kappaB signaling pathway, but also uncovers a new mechanism of crosstalk between NF-kappaB signaling and autophagy pathways.
Title: LRRC25 Functions as an Inhibitor of NF-κB Signaling Pathway by Promoting p65/RelA for Autophagic Degradation.
LRRC25 as a critical molecular switch whose down-regulation resulted in cardiac hypertrophy in a TGF-beta1- and NF-kappaB-dependent manner.
Title: Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1.
The findings identify a previously unrecognized role of LRRC25 in type I interferon signaling activation by which LRRC25 acts as a secondary receptor to assist RIG-I delivery to autophagosomes for degradation in a p62-dependent manner.
Title: LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S16 (e-PCR)
- UniSTS:155756

NoName (e-PCR)
- UniSTS:484318

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 25

Names: monocyte and plasmacytoid activated molecule; monocyte and plasmacytoid-activated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145256.3 → NP_660299.2 leucine-rich repeat-containing protein 25 precursor

See identical proteins and their annotated locations for NP_660299.2

Status: VALIDATED

Source sequence(s)

AC008397, AJ422148, AK095435, AY358151, BC033825, BI910095

Consensus CDS

CCDS12377.1

UniProtKB/Swiss-Prot

Q6IQ00, Q8N386, Q8N9A5

Related

ENSP00000340983.2, ENST00000339007.4

Conserved Domains (3) summary

sd00031
Location:63 → 86

LRR_1; leucine-rich repeat [structural motif]

pfam11770
Location:168 → 303

GAPT; GRB2-binding adapter (GAPT)

pfam12799
Location:62 → 102

LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

18391137..18397622 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005259739.5 → XP_005259796.1 leucine-rich repeat-containing protein 25 isoform X1

See identical proteins and their annotated locations for XP_005259796.1

UniProtKB/Swiss-Prot

Q6IQ00, Q8N386, Q8N9A5

Related

ENSP00000472290.1, ENST00000595840.1

Conserved Domains (3) summary

sd00031
Location:63 → 86

LRR_1; leucine-rich repeat [structural motif]

pfam11770
Location:168 → 303

GAPT; GRB2-binding adapter (GAPT)

pfam12799
Location:62 → 102

LRR_4; Leucine Rich repeats (2 copies)