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    Zfp641 zinc finger protein 641 [ Mus musculus (house mouse) ]

    Gene ID: 239652, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp641provided by MGI
    Official Full Name
    zinc finger protein 641provided by MGI
    Primary source
    MGI:MGI:2442788
    See related
    Ensembl:ENSMUSG00000022987 AllianceGenome:MGI:2442788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf641; 9930016F01Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleoplasm. Orthologous to human ZNF641 (zinc finger protein 641). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 6.6), lung adult (RPKM 3.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp641 in Genome Data Viewer
    Location:
    15 F1; 15 54.29 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98183466..98194395, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98285585..98296515, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily AD member 1B Neighboring gene STARR-seq mESC enhancer starr_39658 Neighboring gene H1.7 linker histone Neighboring gene predicted gene, 33967 Neighboring gene STARR-seq mESC enhancer starr_39659 Neighboring gene olfactory receptor family 8 subfamily S member 16 Neighboring gene STARR-seq mESC enhancer starr_39660 Neighboring gene STARR-seq mESC enhancer starr_39661 Neighboring gene olfactory receptor family 8 subfamily S member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 641

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358068.1 → NP_001344997.1  zinc finger protein 641 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC105982
      Consensus CDS
      CCDS88831.1
      Related
      ENSMUSP00000023722.6, ENSMUST00000023722.12
      Conserved Domains (4) summary
      PLN03206
      Location:2 → 118
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:91 → 141
      KRAB; krueppel associated box
      COG5048
      Location:223 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_173769.4 → NP_776130.1  zinc finger protein 641 isoform 1

      See identical proteins and their annotated locations for NP_776130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC105982
      Consensus CDS
      CCDS27789.1
      UniProtKB/Swiss-Prot
      Q14DN8, Q8BZ34
      Related
      ENSMUSP00000133212.2, ENSMUST00000169721.3
      Conserved Domains (4) summary
      PLN03206
      Location:2 → 90
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:95 → 155
      KRAB; krueppel associated box
      COG5048
      Location:237 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98183466..98194395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316604.3 → XP_017172093.1  zinc finger protein 641 isoform X2

      UniProtKB/Swiss-Prot
      Q8BZ34
      Conserved Domains (4) summary
      PLN03206
      Location:2 → 118
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:91 → 141
      KRAB; krueppel associated box
      COG5048
      Location:223 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006520970.5 → XP_006521033.1  zinc finger protein 641 isoform X1

      See identical proteins and their annotated locations for XP_006521033.1

      UniProtKB/Swiss-Prot
      Q14DN8, Q8BZ34
      Conserved Domains (4) summary
      PLN03206
      Location:2 → 90
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:95 → 155
      KRAB; krueppel associated box
      COG5048
      Location:237 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036159406.1 → XP_036015299.1  zinc finger protein 641 isoform X5

      Conserved Domains (3) summary
      COG5048
      Location:229 → 290
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:128 → 148
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:154 → 176
      zf-C2H2; Zinc finger, C2H2 type

    4. XM_006520971.5 → XP_006521034.1  zinc finger protein 641 isoform X2

      See identical proteins and their annotated locations for XP_006521034.1

      UniProtKB/Swiss-Prot
      Q8BZ34
      Conserved Domains (4) summary
      PLN03206
      Location:2 → 118
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:91 → 141
      KRAB; krueppel associated box
      COG5048
      Location:223 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238 → 258
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_011245627.4 → XP_011243929.1  zinc finger protein 641 isoform X1

      See identical proteins and their annotated locations for XP_011243929.1

      UniProtKB/Swiss-Prot
      Q14DN8, Q8BZ34
      Conserved Domains (4) summary
      PLN03206
      Location:2 → 90
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:95 → 155
      KRAB; krueppel associated box
      COG5048
      Location:237 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_006520969.5 → XP_006521032.1  zinc finger protein 641 isoform X1

      See identical proteins and their annotated locations for XP_006521032.1

      UniProtKB/Swiss-Prot
      Q14DN8, Q8BZ34
      Conserved Domains (4) summary
      PLN03206
      Location:2 → 90
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:95 → 155
      KRAB; krueppel associated box
      COG5048
      Location:237 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252 → 272
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_006520974.4 → XP_006521037.1  zinc finger protein 641 isoform X4

      Conserved Domains (3) summary
      smart00349
      Location:48 → 99
      KRAB; krueppel associated box
      COG5048
      Location:181 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:196 → 216
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_006520973.5 → XP_006521036.1  zinc finger protein 641 isoform X3

      Conserved Domains (3) summary
      smart00349
      Location:53 → 113
      KRAB; krueppel associated box
      COG5048
      Location:195 → 365
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_875298.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ34.1 GenPept UniProtKB/Swiss-Prot:Q8BZ34

    Gene LinkOut

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