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    Ogdhl oxoglutarate dehydrogenase-like [ Mus musculus (house mouse) ]

    Gene ID: 239017, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ogdhlprovided by MGI
    Official Full Name
    oxoglutarate dehydrogenase-likeprovided by MGI
    Primary source
    MGI:MGI:3616088
    See related
    Ensembl:ENSMUSG00000021913 AllianceGenome:MGI:3616088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Predicted to be involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in heart. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome. Orthologous to human OGDHL (oxoglutarate dehydrogenase L). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 30.8), cerebellum adult (RPKM 18.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ogdhl in Genome Data Viewer
    Location:
    14 B; 14 19.4 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32043941..32070108)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32321982..32348151)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene tetratricopeptide repeat domain 35 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36341 Neighboring gene predicted gene, 48914 Neighboring gene predicted gene, 52134 Neighboring gene RIKEN cDNA 1700024G13 gene Neighboring gene STARR-seq mESC enhancer starr_36344 Neighboring gene choline O-acetyltransferase Neighboring gene solute carrier family 18 (vesicular monoamine), member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway. Yousefi K, et al. J Am Coll Cardiol, 2019 Jun 4. PMID 31146816, Free PMC Article
    2. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
    3. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
    4. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. Grose JH, et al. PLoS One, 2015. PMID 26465331, Free PMC Article
    5. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2-oxoglutarate dehydrogenase-like, mitochondrial
    NP_001074599.2
    XP_030103646.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081130.2 → NP_001074599.2  2-oxoglutarate dehydrogenase-like, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AC167565, BC157970
      Consensus CDS
      CCDS36866.2
      UniProtKB/TrEMBL
      B2RXT3, E9Q7L0
      Related
      ENSMUSP00000154185.2, ENSMUST00000228529.2
      Conserved Domains (1) summary
      PRK09404
      Location:45 → 1001
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      32043941..32070108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247786.2 → XP_030103646.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl39092
      Location:45 → 714
      SucA; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version

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