Ormdl3 ORM1-like 3 (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ormdl3provided by MGI
Official Full Name: ORM1-like 3 (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1913862
See related: Ensembl:ENSMUSG00000038150 AllianceGenome:MGI:1913862
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810011N17Rik
Summary: Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and negative regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum. Predicted to be part of serine palmitoyltransferase complex. Is expressed in lung. Orthologous to human ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 93.0), subcutaneous fat pad adult (RPKM 91.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.07 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98472120..98478071, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98581294..98587245, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis.
Title: Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis.
Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis.
Title: Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis.
Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice.
Title: Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice.
ORMDL3-mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma.
Title: ORMDL3‑mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma.
The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway.
Title: The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway.
Ormdl3 regulation of specific ceramides is dispensable for mouse beta-cell function and glucose homeostasis under obesogenic conditions.
Title: Ormdl3 regulation of specific ceramides is dispensable for mouse β-cell function and glucose homeostasis under obesogenic conditions.
Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice.
Title: Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice.
Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation.
Title: Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation.
Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways.
Title: Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways.
Pulmonary delivery of ORMDL3 short hairpin RNA - a potential tool to regulate allergen-induced airway inflammation.
Title: Pulmonary delivery of ORMDL3 short hairpin RNA - a potential tool to regulate allergen-induced airway inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular sphingolipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of motor behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of myelination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of serine C-palmitoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of autophagy	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of regulation of ceramide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of regulation of ceramide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of sphingolipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of regulation of sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of sphingomyelin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of sphingomyelin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of serine palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of serine palmitoyltransferase complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of serine palmitoyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ORM1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025661.4 → NP_079937.1 ORM1-like protein 3

Status: PROVISIONAL

Source sequence(s)

AL591125

Consensus CDS

CCDS25355.1

UniProtKB/Swiss-Prot

A2A4X7, Q8BN65, Q8R0U5, Q9CPZ6

Related

ENSMUSP00000053056.8, ENSMUST00000052919.8

Conserved Domains (1) summary

pfam04061
Location:11 → 146

ORMDL; ORMDL family