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    Trir telomerase RNA component interacting RNase [ Mus musculus (house mouse) ]

    Gene ID: 68544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trirprovided by MGI
    Official Full Name
    telomerase RNA component interacting RNaseprovided by MGI
    Primary source
    MGI:MGI:1922833
    See related
    Ensembl:ENSMUSG00000041203 AllianceGenome:MGI:1922833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110002H14Rik; 2310036O22Rik
    Summary
    Predicted to enable 3'-5' exonuclease activity and 5'-3' exonuclease activity. Predicted to be involved in rRNA catabolic process. Orthologous to human TRIR (telomerase RNA component interacting RNase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 80.0), CNS E14 (RPKM 55.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trir in Genome Data Viewer
    Location:
    8 C3; 8 41.49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85753440..85756920)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85026811..85030291)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene bestrophin 2 Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene STARR-positive B cell enhancer ABC_E884 Neighboring gene STARR-positive B cell enhancer ABC_E8254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87560506-87560689 Neighboring gene transportin 2 (importin 3, karyopherin beta 2b) Neighboring gene RIKEN cDNA A230103J11 gene Neighboring gene predicted gene, 25506 Neighboring gene STARR-seq mESC enhancer starr_22150 Neighboring gene F-box and WD-40 domain protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). White RA, et al. Blood Cells Mol Dis, 2009 Sep-Oct. PMID 19409822
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-3' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    telomerase RNA component interacting RNase
    Names
    exoribonuclease Trir
    exoribonuclease TrirR
    uncharacterized protein C19orf43 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026760.3 → NP_081036.2  telomerase RNA component interacting RNase

      See identical proteins and their annotated locations for NP_081036.2

      Status: VALIDATED

      Source sequence(s)
      AC163703
      Consensus CDS
      CCDS22490.1
      UniProtKB/Swiss-Prot
      Q9D1N3, Q9D735
      Related
      ENSMUSP00000044129.9, ENSMUST00000047281.10

    RNA

    1. NR_160793.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163703

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85753440..85756920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243748.1 → XP_030099608.1  telomerase RNA component interacting RNase isoform X2

    2. XM_030243747.2 → XP_030099607.1  telomerase RNA component interacting RNase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D735.1 GenPept UniProtKB/Swiss-Prot:Q9D735

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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