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    Ppef1 protein phosphatase with EF hand calcium-binding domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 237178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppef1provided by MGI
    Official Full Name
    protein phosphatase with EF hand calcium-binding domain 1provided by MGI
    Primary source
    MGI:MGI:1097157
    See related
    Ensembl:ENSMUSG00000062168 AllianceGenome:MGI:1097157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PPEF-1
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in detection of stimulus involved in sensory perception. Predicted to be active in cytosol and nucleus. Is expressed in ear and nervous system. Orthologous to human PPEF1 (protein phosphatase with EF-hand domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.6), CNS E14 (RPKM 0.1) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Ppef1 in Genome Data Viewer
    Location:
    X F4; X 73.95 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (159404997..159534286, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (160622419..160751290, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor G2 Neighboring gene predicted gene 15241 Neighboring gene phosphorylase kinase alpha 2 Neighboring gene STARR-seq mESC enhancer starr_48183 Neighboring gene STARR-seq mESC enhancer starr_48184 Neighboring gene nuclear encoded tRNA valine 3 (anticodon TAC) Neighboring gene STARR-seq mESC enhancer starr_48186 Neighboring gene retinoschisis (X-linked, juvenile) 1 (human) Neighboring gene cyclin dependent kinase like 5 Neighboring gene gap junction protein, alpha 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility. Lavoie-Ouellet C, et al. Mol Reprod Dev, 2021 Apr. PMID 33783058
    2. Drosophila-related expressed sequences. Banfi S, et al. Hum Mol Genet, 1997. PMID 9300667
    3. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. Sherman PM, et al. Proc Natl Acad Sci U S A, 1997 Oct 14. PMID 9326663, Free PMC Article
    4. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2). Ramulu P, et al. Mol Cell Biol, 2001 Dec. PMID 11713293, Free PMC Article
    5. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin. Montini E, et al. Hum Mol Genet, 1997 Jul. PMID 9215685

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility.
      Title: The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of stimulus involved in sensory perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase with EF-hands 1
    Names
    DRES10
    PPEF 1
    protein phosphatase with EF calcium-binding domain
    NP_035277.1
    XP_011246120.1
    XP_017173969.1
    XP_017173970.1
    XP_030107195.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011147.1 → NP_035277.1  serine/threonine-protein phosphatase with EF-hands 1

      See identical proteins and their annotated locations for NP_035277.1

      Status: VALIDATED

      Source sequence(s)
      AL732450, AL974311
      Consensus CDS
      CCDS41200.1
      UniProtKB/Swiss-Prot
      A2AIC6, O35655
      Related
      ENSMUSP00000071191.6, ENSMUST00000071204.12
      Conserved Domains (4) summary
      smart00156
      Location:137 → 456
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd00051
      Location:571 → 636
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd07420
      Location:118 → 453
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
      pfam13499
      Location:575 → 636
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      159404997..159534286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251335.2 → XP_030107195.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X3

      Conserved Domains (3) summary
      PTZ00183
      Location:436 → 578
      PTZ00183; centrin; Provisional
      cd07420
      Location:62 → 397
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
      pfam13499
      Location:513 → 581
      EF-hand_7; EF-hand domain pair

    2. XM_017318481.2 → XP_017173970.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X2

      Conserved Domains (3) summary
      PTZ00183
      Location:497 → 639
      PTZ00183; centrin; Provisional
      cd07420
      Location:123 → 458
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
      pfam13499
      Location:574 → 642
      EF-hand_7; EF-hand domain pair

    3. XM_017318480.2 → XP_017173969.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X1

      Conserved Domains (3) summary
      PTZ00183
      Location:518 → 660
      PTZ00183; centrin; Provisional
      cd07420
      Location:144 → 479
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
      pfam13499
      Location:595 → 663
      EF-hand_7; EF-hand domain pair

    4. XM_011247818.2 → XP_011246120.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X1

      See identical proteins and their annotated locations for XP_011246120.1

      Conserved Domains (3) summary
      PTZ00183
      Location:518 → 660
      PTZ00183; centrin; Provisional
      cd07420
      Location:144 → 479
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
      pfam13499
      Location:595 → 663
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35655.2 GenPept UniProtKB/Swiss-Prot:O35655

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