Fem1al fem-1 homolog A like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fem1alprovided by MGI
Official Full Name: fem-1 homolog A likeprovided by MGI
Primary source: MGI:MGI:2441689
See related: Ensembl:ENSMUSG00000078157 AllianceGenome:MGI:2441689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fem1ab; 4931440F15Rik
Summary: Predicted to enable EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in negative regulation of inflammatory response; regulation of ubiquitin-protein transferase activity; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in mitochondrion. Orthologous to human FEM1A (fem-1 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 11 A3.3; 11 16.96 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (29772395..29775668, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (29822395..29825668, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables EP4 subtype prostaglandin E2 receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein fem-1 homolog A-like

Names: FEM1-alpha-B; FEM1a-B; protein fem-1 homolog A-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176829.2 → NP_789799.1 protein fem-1 homolog A-like

See identical proteins and their annotated locations for NP_789799.1

Status: VALIDATED

Source sequence(s)

AK029918

Consensus CDS

CCDS78924.1

UniProtKB/Swiss-Prot

B2RT26, Q5RJ26, Q8C0T1

Related

ENSMUSP00000100568.3, ENSMUST00000104962.2

Conserved Domains (5) summary

cd00204
Location:110 → 235

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:87 → 179

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:183 → 235

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:552 → 605

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:118 → 147

ANK; ANK repeat [structural motif]