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Nod2 nucleotide-binding oligomerization domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 257632, updated on 9-Dec-2024

Summary

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Official Symbol: Nod2provided by MGI
Official Full Name: nucleotide-binding oligomerization domain containing 2provided by MGI
Primary source: MGI:MGI:2429397
See related: Ensembl:ENSMUSG00000055994 AllianceGenome:MGI:2429397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik
Summary: Enables muramyl dipeptide binding activity and pattern recognition receptor activity. Involved in several processes, including host-mediated regulation of intestinal microbiota composition; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of MAPK cascade; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Predicted to be extrinsic component of plasma membrane. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 1.5), spleen adult (RPKM 1.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

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See Nod2 in Genome Data Viewer

Location:: 8 C3; 8 43.51 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (89373943..89415103)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (88647315..88688474)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages.
Title: NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages.
Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner.
Title: Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner.
Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis.
Title: Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis.
NOD2 in monocytes negatively regulates macrophage development through TNFalpha.
Title: NOD2 in monocytes negatively regulates macrophage development through TNFalpha.
Growing up: A NOD2 our microbes.
Title: Growing up: A NOD2 our microbes.
NOD2 inhibits the proliferation of esophageal adenocarcinoma cells through autophagy.
Title: NOD2 inhibits the proliferation of esophageal adenocarcinoma cells through autophagy.
The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses.
Title: The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses.
Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function.
Title: Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function.
Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Title: Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
Mice Dually Disrupted for Nod2 and Mincle Manifest Early Bacteriological Control but Late Susceptibility During Mycobacterium tuberculosis Infection.
Title: Mice Dually Disrupted for Nod2 and Mincle Manifest Early Bacteriological Control but Late Susceptibility During Mycobacterium tuberculosis Infection.

Submit: New GeneRIF Correction See all GeneRIFs (241)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables CARD domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables muramyl dipeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables muramyl dipeptide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables muramyl dipeptide binding	ISO Inferred from Sequence Orthology more info
enables muramyl dipeptide binding	ISS Inferred from Sequence or Structural Similarity more info
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to muramyl dipeptide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of biotic stimulus	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within detection of muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in detection of muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in detection of muramyl dipeptide	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in host-mediated regulation of intestinal microbiota composition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within innate immune response in mucosa	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-18 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage inflammatory protein-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of gastrointestinal epithelium	IEA Inferred from Electronic Annotation more info
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-18 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of toll-like receptor 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of antibacterial peptide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte chemotactic protein-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of xenophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to muramyl dipeptide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to muramyl dipeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muramyl dipeptide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to muramyl dipeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to muramyl dipeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in response to muramyl dipeptide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to peptidoglycan	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of toll-like receptor 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of xenophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in extrinsic component of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleotide-binding oligomerization domain-containing protein 2

Names: caspase recruitment domain family, member 15; caspase recruitment domain-containing protein 15

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145857.2 → NP_665856.2 nucleotide-binding oligomerization domain-containing protein 2

See identical proteins and their annotated locations for NP_665856.2

Status: VALIDATED

Source sequence(s)

AC156937

Consensus CDS

CCDS52632.1

UniProtKB/TrEMBL

Q80SY8, Q80SY9, Q80SZ8

Related

ENSMUSP00000113773.2, ENSMUST00000118370.8

Conserved Domains (4) summary

cd00116
Location:753 → 980

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:768 → 789

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

cl14633
Location:107 → 186

DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

89373943..89415103

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248390.3 → XP_011246692.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_011246692.1

UniProtKB/TrEMBL

Q80SZ8

Conserved Domains (6) summary

sd00033
Location:768 → 789

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

pfam17776
Location:576 → 730

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:518 → 574

NOD2_WH; NOD2 winged helix domain

cl14633
Location:107 → 186

DD; Death Domain Superfamily of protein-protein interaction domains

cl39015
Location:753 → 981

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_036154050.1 → XP_036009943.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

Q80SZ8

Conserved Domains (6) summary

sd00033
Location:762 → 780

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

pfam17776
Location:576 → 730

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:518 → 574

NOD2_WH; NOD2 winged helix domain

cl14633
Location:107 → 186

DD; Death Domain Superfamily of protein-protein interaction domains

cl39015
Location:753 → 979

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006531029.5 → XP_006531092.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

Q80SZ8

Conserved Domains (6) summary

sd00033
Location:762 → 780

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

pfam17776
Location:576 → 730

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:518 → 574

NOD2_WH; NOD2 winged helix domain

cl14633
Location:107 → 186

DD; Death Domain Superfamily of protein-protein interaction domains

cl39015
Location:753 → 934

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_036154051.1 → XP_036009944.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X4

UniProtKB/TrEMBL

Q3V2V8

Related

ENSMUST00000124091.2

Conserved Domains (4) summary

pfam05729
Location:266 → 436

NACHT; NACHT domain

pfam17776
Location:576 → 730

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:518 → 574

NOD2_WH; NOD2 winged helix domain

cl14633
Location:7 → 87

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006531028.4 → XP_006531091.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006531091.1

UniProtKB/TrEMBL

Q80SZ8

Conserved Domains (6) summary

sd00033
Location:768 → 789

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

pfam17776
Location:576 → 730

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:518 → 574

NOD2_WH; NOD2 winged helix domain

cl14633
Location:107 → 186

DD; Death Domain Superfamily of protein-protein interaction domains

cl39015
Location:753 → 981

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...