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    Cyp3a41b cytochrome P450, family 3, subfamily a, polypeptide 41B [ Mus musculus (house mouse) ]

    Gene ID: 100041375, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp3a41bprovided by MGI
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 41Bprovided by MGI
    Primary source
    MGI:MGI:3714859
    See related
    Ensembl:ENSMUSG00000075552 AllianceGenome:MGI:3714859
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable demethylase activity; retinoic acid 4-hydroxylase activity; and steroid hydroxylase activity. Acts upstream of or within response to bacterium. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver adult (RPKM 124.9) See more
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    Genomic context

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    See Cyp3a41b in Genome Data Viewer
    Location:
    5 G2; 5 85.17 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145495474..145521542, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145558664..145584732, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 3, subfamily a, member 58, pseudogene Neighboring gene zinc finger protein 498 pseudogene Neighboring gene selenoprotein K, pseudogene 7 Neighboring gene cytochrome P450, family 3, subfamily a, member 63, pseudogene Neighboring gene STARR-seq mESC enhancer starr_14834

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel female-specific member of the CYP3A gene subfamily in the mouse liver. Sakuma T, et al. Arch Biochem Biophys, 2000 May 1. PMID 10775455
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables demethylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estrogen 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinoic acid 4-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alkaloid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxidative demethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 3A41
    NP_001098629.1
    XP_017176060.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105159.1 → NP_001098629.1  cytochrome P450 3A41

      See identical proteins and their annotated locations for NP_001098629.1

      Status: PROVISIONAL

      Source sequence(s)
      AC124483
      Consensus CDS
      CCDS39389.1
      UniProtKB/Swiss-Prot
      B2RQU5, E9QJT9, Q9JMA7
      UniProtKB/TrEMBL
      Q52L54
      Related
      ENSMUSP00000075234.7, ENSMUST00000075837.8
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 494
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145495474..145521542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320571.1 → XP_017176060.1  cytochrome P450 3A41 isoform X1

      UniProtKB/TrEMBL
      Q52L54
      Conserved Domains (1) summary
      pfam00067
      Location:23 → 445
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMA7.2 GenPept UniProtKB/Swiss-Prot:Q9JMA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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