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    Gpr55 G protein-coupled receptor 55 [ Mus musculus (house mouse) ]

    Gene ID: 227326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr55provided by MGI
    Official Full Name
    G protein-coupled receptor 55provided by MGI
    Primary source
    MGI:MGI:2685064
    See related
    Ensembl:ENSMUSG00000049608 AllianceGenome:MGI:2685064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTFL; Gm218; Lpir1
    Summary
    Predicted to enable cannabinoid receptor activity. Predicted to be involved in several processes, including bone resorption; negative regulation of osteoclast differentiation; and positive regulation of intracellular signal transduction. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; forebrain; neural retina; and retina. Orthologous to human GPR55 (G protein-coupled receptor 55). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 1.4), small intestine adult (RPKM 1.0) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr55 in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85860927..85924781, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85933221..85991583, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32302 Neighboring gene predicted gene, 51745 Neighboring gene RIKEN cDNA 4933407L21 gene Neighboring gene STARR-seq mESC enhancer starr_01557 Neighboring gene predicted gene, 41905 Neighboring gene STARR-positive B cell enhancer ABC_E5777 Neighboring gene predicted gene, 53569 Neighboring gene zinc finger protein 617 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination. Wu CS, et al. PLoS One, 2013. PMID 23565223, Free PMC Article
    2. Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice. Carey LM, et al. Sci Rep, 2017 Apr 20. PMID 28428628, Free PMC Article
    3. A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity. Hurst K, et al. Hippocampus, 2017 Sep. PMID 28653801, Free PMC Article
    4. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress. Shi QX, et al. Mol Brain, 2017 Aug 11. PMID 28800762, Free PMC Article
    5. GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR-independent suppression of Na(+)-Ca(2+) exchanger and endoplasmic reticulum Ca(2+) refilling. Bondarenko AI, et al. Vascul Pharmacol, 2017 Feb. PMID 28064014, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Global deletion of G protein-coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and beta-cell turnover.
      Title: Global deletion of G protein-coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β-cell turnover.
    2. GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice.
      Title: GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice.
    3. GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice.
      Title: GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice.
    4. Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome.
      Title: Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome.
    5. Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice.
      Title: Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice.
    6. The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice.
      Title: The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice.
    7. Activation of GPR55 attenuates cognitive impairment, oxidative stress, neuroinflammation, and synaptic dysfunction in a streptozotocin-induced Alzheimer's mouse model.
      Title: Activation of GPR55 attenuates cognitive impairment, oxidative stress, neuroinflammation, and synaptic dysfunction in a streptozotocin-induced Alzheimer's mouse model.
    8. Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning.
      Title: Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning.
    9. Cannabinoid receptor GPR55 activation blocks nicotine use disorder by regulation of AMPAR phosphorylation.
      Title: Cannabinoid receptor GPR55 activation blocks nicotine use disorder by regulation of AMPAR phosphorylation.
    10. GPR55 regulates the responsiveness to, but does not dimerise with, alpha1A-adrenoceptors.
      Title: GPR55 regulates the responsiveness to, but does not dimerise with, α(1A)-adrenoceptors.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cannabinoid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cannabinoid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cannabinoid receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bone resorption IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cannabinoid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033290.3 → NP_001028462.2  G-protein coupled receptor 55

      See identical proteins and their annotated locations for NP_001028462.2

      Status: VALIDATED

      Source sequence(s)
      AC102506, AC107707
      Consensus CDS
      CCDS15115.1
      UniProtKB/Swiss-Prot
      Q3UJF0
      UniProtKB/TrEMBL
      Q14BV9
      Related
      ENSMUSP00000084196.5, ENSMUST00000086975.7
      Conserved Domains (2) summary
      cd14964
      Location:20 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:20 → 305
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      85860927..85924781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320337.3 → XP_017175826.1  G-protein coupled receptor 55 isoform X4

      UniProtKB/Swiss-Prot
      Q3UJF0
      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:20 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:20 → 305
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_011247986.4 → XP_011246288.1  G-protein coupled receptor 55 isoform X1

      See identical proteins and their annotated locations for XP_011246288.1

      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:48 → 75
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:48 → 333
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_006529459.5 → XP_006529522.1  G-protein coupled receptor 55 isoform X2

      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:37 → 64
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37 → 322
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_036164492.1 → XP_036020385.1  G-protein coupled receptor 55 isoform X4

      UniProtKB/Swiss-Prot
      Q3UJF0
      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:20 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:20 → 305
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_030253716.2 → XP_030109576.1  G-protein coupled receptor 55 isoform X4

      UniProtKB/Swiss-Prot
      Q3UJF0
      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:20 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:20 → 305
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_030253705.2 → XP_030109565.1  G-protein coupled receptor 55 isoform X1

      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:48 → 75
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:48 → 333
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_030253706.2 → XP_030109566.1  G-protein coupled receptor 55 isoform X1

      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:48 → 75
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:48 → 333
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. XM_030253715.2 → XP_030109575.1  G-protein coupled receptor 55 isoform X3

      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:32 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32 → 317
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    9. XM_030253712.2 → XP_030109572.1  G-protein coupled receptor 55 isoform X2

      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:37 → 64
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:37 → 322
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    10. XM_030253718.2 → XP_030109578.1  G-protein coupled receptor 55 isoform X4

      UniProtKB/Swiss-Prot
      Q3UJF0
      UniProtKB/TrEMBL
      Q14BV9
      Conserved Domains (2) summary
      cd14964
      Location:20 → 47
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:20 → 305
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UJF0.2 GenPept UniProtKB/Swiss-Prot:Q3UJF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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