Tube1 tubulin, epsilon 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tube1provided by MGI
Official Full Name: tubulin, epsilon 1provided by MGI
Primary source: MGI:MGI:1919174
See related: Ensembl:ENSMUSG00000019845 AllianceGenome:MGI:1919174
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tube; 2310061K05Rik
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in centrosome. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including central nervous system; eye; and palatal shelf. Orthologous to human TUBE1 (tubulin epsilon 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in thymus adult (RPKM 18.3), CNS E11.5 (RPKM 7.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 20.16 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (39009946..39035863)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (39133949..39151058)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin epsilon chain

Names: epsilon-tubulin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028006.2 → NP_082282.1 tubulin epsilon chain

Status: PROVISIONAL

Source sequence(s)

AK148039

Consensus CDS

CCDS23787.1

UniProtKB/Swiss-Prot

Q9D6T1

Related

ENSMUSP00000019991.8, ENSMUST00000019991.8

Conserved Domains (1) summary

cd02190
Location:2 → 457

epsilon_tubulin; The epsilon-tubulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

39009946..39035863

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156032.1 → XP_036011925.1 tubulin epsilon chain isoform X3

Conserved Domains (1) summary

cl10017
Location:2 → 318

Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
XM_036156030.1 → XP_036011923.1 tubulin epsilon chain isoform X1

UniProtKB/Swiss-Prot

Q9D6T1

Conserved Domains (1) summary

cd02190
Location:2 → 457

epsilon_tubulin; The epsilon-tubulin family
XM_036156029.1 → XP_036011922.1 tubulin epsilon chain isoform X1

UniProtKB/Swiss-Prot

Q9D6T1

Conserved Domains (1) summary

cd02190
Location:2 → 457

epsilon_tubulin; The epsilon-tubulin family
XM_036156031.1 → XP_036011924.1 tubulin epsilon chain isoform X1

UniProtKB/Swiss-Prot

Q9D6T1

Conserved Domains (1) summary

cd02190
Location:2 → 457

epsilon_tubulin; The epsilon-tubulin family
XM_006512861.5 → XP_006512924.1 tubulin epsilon chain isoform X2

Conserved Domains (1) summary

cd02190
Location:1 → 382

epsilon_tubulin; The epsilon-tubulin family