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    Ccr1l1 C-C motif chemokine receptor 1 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 12770, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ccr1l1provided by MGI
    Official Full Name
    C-C motif chemokine receptor 1 like 1provided by MGI
    Primary source
    MGI:MGI:104617
    See related
    Ensembl:ENSMUSG00000064039 AllianceGenome:MGI:104617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cmkbr1l1
    Summary
    Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including monocyte chemotaxis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of monocyte chemotaxis. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See Ccr1l1 in Genome Data Viewer
    Location:
    9 F4; 9 75.05 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123776467..123786752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123976430..123986715, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51701 Neighboring gene STARR-positive B cell enhancer ABC_E5116 Neighboring gene C-C motif chemokine receptor 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123900979-123901280 Neighboring gene C-C motif chemokine receptor 3 Neighboring gene C-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC156358

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding  
    enables C-C chemokine receptor activity  
    enables C-C chemokine receptor activity  
    enables C-C chemokine receptor activity  
    enables chemokine (C-C motif) ligand 5 binding  
    enables chemokine (C-C motif) ligand 5 binding  
    enables chemokine (C-C motif) ligand 7 binding  
    enables chemokine (C-C motif) ligand 7 binding  
    enables chemokine receptor activity  
    enables phosphatidylinositol phospholipase C activity  
    Process Evidence Code Pubs
    involved_in calcium ion transport  
    involved_in calcium-mediated signaling  
    involved_in cell chemotaxis  
    involved_in cell-cell signaling  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemotaxis  
    involved_in exocytosis  
    involved_in immune response  
    involved_in immune response  
    involved_in immune response  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in intracellular calcium ion homeostasis  
    involved_in monocyte chemotaxis  
    involved_in negative regulation of bone mineralization  
    involved_in negative regulation of gene expression  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of calcium ion transport  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of monocyte chemotaxis  
    involved_in positive regulation of monocyte chemotaxis  
    involved_in positive regulation of osteoclast differentiation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    C-C chemokine receptor 1-like protein 1
    Names
    MIP-1 alphaRL1
    chemokine (C-C motif) receptor 1-like 1
    chemokine (C-C) receptor 1-like 1
    macrophage inflammatory protein-1 alpha receptor-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007718.4NP_031744.3  C-C chemokine receptor 1-like protein 1

      See identical proteins and their annotated locations for NP_031744.3

      Status: VALIDATED

      Source sequence(s)
      AC140491
      Consensus CDS
      CCDS23667.1
      UniProtKB/Swiss-Prot
      A0JP35, P51676
      Related
      ENSMUSP00000071353.4, ENSMUST00000071404.5
      Conserved Domains (1) summary
      pfam00001
      Location:52302
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      123776467..123786752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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