sulf1 sulfatase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sulf1provided by ZNC
Official Full Name: sulfatase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9242
See related: Ensembl:ENSDARG00000038428 AllianceGenome:ZFIN:ZDB-GENE-030131-9242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fk14e08
Summary: Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Acts upstream of or within with a positive effect on epithelial structure maintenance. Acts upstream of or within several processes, including neuromast deposition; regulation of myotome development; and vasculogenesis. Predicted to be located in Golgi stack. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; head; hypochord; and somite. Orthologous to human SULF1 (sulfatase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (19518559..19587535)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (19374157..19443110)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish.
Title: Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish.
lack of SULF1 expression downregulates VEGFA-mediated arterial marker expression, confirming that Sulf1 mediates arterial specification by regulating VegfA165 activity.
Title: The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity.
Sulf1 triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors
Title: Dynamics of sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring sulfatase 1.
Data indicate that sulf1 plays a crucial role in modulating both BMP and FGF signaling.
Title: Sulf1 modulates BMP signaling and is required for somite morphogenesis and development of the horizontal myoseptum.
Zebrafish sulf1 and sulf2a are broadly expressed in the central nervous system (CNS) and non-neuronal tissue including heart, somite boundaries, olfactory system, and otic vesicle.
Title: Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2.

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General gene information

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Markers

fk14e08.x1 (e-PCR)
- UniSTS:200606

fj77h09.y1 (e-PCR)
- UniSTS:199880

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acetylglucosamine-6-sulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sulfuric ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect epithelial structure maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular basement membrane development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromast deposition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of myotome development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: extracellular sulfatase Sulf-1

Names: sulfatase FP1c

NP_001003846.1

EC 3.1.6.-

XP_068073137.1

EC 3.1.6.-

XP_068073138.1

EC 3.1.6.-

XP_068073139.1

EC 3.1.6.-

XP_068073140.1

EC 3.1.6.-

XP_068073141.1

EC 3.1.6.-

XP_068073142.1

EC 3.1.6.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003846.2 → NP_001003846.1 extracellular sulfatase Sulf-1 precursor

See identical proteins and their annotated locations for NP_001003846.1

Status: VALIDATED

Source sequence(s)

CR382282, CR385071

UniProtKB/TrEMBL

A0A8M1N1N4, Q6EFA1

Related

ENSDARP00000056080.2, ENSDART00000056081.4

Conserved Domains (4) summary

COG3119
Location:41 → 392

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

pfam12548
Location:540 → 675

DUF3740; Sulfatase protein

cd16147
Location:41 → 383

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

cl23718
Location:770 → 819

ALP_like; alkaline phosphatases and sulfatases